Association of the MMP-9 polymorphism and ischemic stroke risk in southern Chinese Han population
Association of the MMP-9 polymorphism and ischemic stroke risk in southern Chinese Han population
复制标题
MMP-9多态性与中国南方汉族人群缺血性脑卒中风险的关系
DOI：
10.1186/s12883-019-1285-7
复制
发表时间：
2019-04-16
期刊：
影响因子：
2.6
通讯作者：
Xia, Ying
中科院分区：
文献类型：
--
作者：
Gao, Ning;Guo, Tie;Xia, Ying
背景：脑卒中是一种严重的心血管疾病，也是发展中国家和发达国家长期残疾的主要原因。由于基质金属蛋白酶-9（MMP-9）与许多心血管疾病的风险相关，我们研究了MMP-9单核苷酸多态性（SNPs）与中国南方汉族人群缺血性卒中（IS）风险的关系。使用MassARRAY系统进行基因分型，并使用卡方检验和遗传模型来评估MMP-9 SNP与IS风险之间的关联。结果：rs3787268多态性与IS的发病危险性相关。在共显性模型中，基因型“G/A”与IS风险显著相关[比值比（OR）= 1.62; 95%可信区间（CI）= 1.10-2.41; p = 0.035]，而在显性模型中，基因型“G/A”和“A/A”可能增加IS的风险（OR = 1.62; 95%CI = 1.12-2.35; p = 0.0097）。在对数相加模型中，该SNP也与IS风险显著相关（OR = 1.33; 95%CI = 1.03-1.70; p = 0.026）。相反，单倍型“C/G”似乎降低IS的风险（OR = 0.71; 95%CI = 0.54-0.95; p = 0.019）。结论：我们的研究表明，MMP-9基因的rs3787268位点可能会增加中国南方汉族人群IS的风险，从而提供了深入了解IS的发病机制。
Background:Stroke is a serious cardiovascular disease and is also the leading cause of long-term disability in developing and developed countries. Because matrix metalloproteinase-9 (MMP-9) is associated with the risk of many cardiovascular diseases, we investigated the relationship between single nucleotide polymorphisms (SNPs) in MMP-9 and the risk of Ischemic stroke (IS) in a southern Chinese Han population.Methods:This study included 250 stroke patients and 250 healthy controls. Genotyping was performed using the Agena MassARRAY system, and chi-squared tests and genetic models were used to evaluate the associations between MMP-9 SNPs and the risk of IS. Odds ratio (OR) and 95% confidence intervals (CIs) were calculated by unconditional logistic regression adjusted for age.Results:Polymorphism rs3787268 was associated with increased the risk of IS. Specifically, the genotype "G/A" significantly correlated with IS risk in the co-dominant model [odds ratio (OR) = 1.62; 95% confidence interval (CI) = 1.10-2.41; p = 0.035)], while genotypes "G/A" and "A/A" may increase the risk of IS based on the dominant model (OR = 1.62; 95% CI = 1.12-2.35; p = 0.0097). This SNP was also significantly associated with IS risk in the log-additive model (OR = 1.33; 95% CI = 1.03-1.70; p = 0.026). Conversely, haplotype "C/G" appears to reduce the risk of IS (OR = 0.71; 95% CI = 0.54-0.95; p = 0.019).Conclusions:Our study showed that the rs3787268 locus in the MMP-9 gene may increase risk of IS in a southern Chinese Han population and thus provide insight into the IS pathogenesis.