Intratumoral plasmacytoid dendritic cells associate with increased survival in patients with follicular lymphoma
Intratumoral plasmacytoid dendritic cells associate with increased survival in patients with follicular lymphoma
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DOI：
10.3109/10428194.2011.569619
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发表时间：
2011-07-01
影响因子：
2.6
通讯作者：
Kurrer, Michael
中科院分区：
文献类型：
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作者：
Butsch, Raphael;Waelti, Stephan Lukas;Kurrer, Michael
滤泡性淋巴瘤(FL)的基因芯片研究表明，非恶性肿瘤浸润性免疫细胞与患者的生存有关。我们以浆细胞样树突状细胞(PDCs)为研究对象，研究了免疫组织化学方法在组织微阵列中检测到的这类细胞的作用。这些细胞生理性地产生干扰素-α，已用于FL的治疗。PDCs的数量越多，存活率越高，CD3+T细胞的数量也越多。PDC和T细胞之间微弱但显著的相关性反映了pDC在T细胞区的规律性分布。然而，在多因素COX模型中，CD123被证明是一个独立的预后因素。这些发现支持这样的假设，即pDC通过产生干扰素与更好的预后相关。此外，由于Kaplan-Meier图显示PDCs与生存期呈线性关系，CD123免疫组织化学染色可作为FL患者预后的一种工具。
Gene array studies on follicular lymphoma (FL) have associated non-malignant tumor-infiltrating immune cells with patient survival. We examined the role of such cells detectable by immunohistochemistry in a tissue microarray, focusing on plasmacytoid dendritic cells (pDCs). These cells physiologically produce interferon-alpha, which has been used in the therapy of FL. High numbers of pDCs are associated with increased survival, and so are high numbers of CD3+ T cells. The regular distribution of pDCs within T cell areas is reflected by a weak but significant correlation between pDCs and T cells. However, in multivariate Cox models, CD123 proved to be an independent prognostic factor. These findings support the hypothesis of an association of pDCs with better prognosis by producing interferon. Furthermore, due to a linear relationship between pDCs and survival shown by means of Kaplan-Meier plots, immunohistochemical staining of CD123 could serve as a prognostic tool for patients with FL.