Maternal smoking during and after pregnancy and lung function in early adulthood: a prospective study
Maternal smoking during and after pregnancy and lung function in early adulthood: a prospective study
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DOI：
10.1136/thx.2009.116301
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发表时间：
2009-09-01
期刊：
影响因子：
10
通讯作者：
O'Callaghan, M. J.
中科院分区：
文献类型：
--
作者：
Hayatbakhsh, M. R.;Sadasivam, S.;O'Callaghan, M. J.
背景和目的：关于产前吸烟是否会影响后代成年早期的肺功能，目前缺乏证据。本研究旨在探讨（1）在子宫内暴露于母亲吸烟是否与成年早期呼吸功能较差有关； (2)产前吸烟的影响与产后母亲吸烟的影响无关； (3) 产前吸烟与年轻人肺功能之间的联系可以通过孩子的出生体重、吸烟或哮喘病史来解释。方法：数据来自于昆士兰马特大学妊娠研究（一项纵向产前队列）对母亲及其孩子进行的 21 年随访。该研究以 2409 名年轻人（1185 名男性和 1224 名女性）为对象，他们获得了 21 岁时呼吸功能以及母亲怀孕期间和怀孕后吸烟情况的前瞻性数据。 Spirobank G 肺活量计系统用于测量用力肺活量 (FVC)、1 秒用力呼气量 (FEV1) 以及 FVC 25% 至 75% 之间的用力呼气流量 (FEF25-75)。 结果：子宫内暴露于母亲吸烟与男性 FEV1 和 FEF25-75 降低相关（回归系数，-0.16；95% CI， -0.30 至 -0.02），考虑到母亲怀孕后吸烟的情况。子宫内吸烟对年轻人肺功能的影响至少部分可以通过孩子的出生体重和随后的哮喘来解释。结论：产前吸烟对气道生长发育的不利影响可能会持续到成年早期。需要进一步探讨该纵向队列中注意到的性别差异。
Background and aims: There is a paucity of evidence about whether exposure to antenatal smoking impacts on offspring's lung function in early adulthood. This study aimed to examine whether (1) in utero exposure to maternal smoking is related to poorer respiratory functioning in early adulthood; (2) the impact of prenatal smoking is independent of postnatal maternal smoking; and (3) the link between prenatal smoking and a young adult's lung function is explained by the child's birth weight, smoking or history of asthma.Methods: Data were from a 21-year follow-up of mothers and their children recruited into the Mater University of Queensland Study of Pregnancy, a longitudinal prebirth cohort. The study is based on 2409 young adults (1185 males and 1224 females) who had prospective data available on respiratory function at 21 years and maternal smoking during and after pregnancy. A Spirobank G spirometer system was used to measure forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1) and forced expiratory flow between 25% and 75% of FVC (FEF25-75).Results: In utero exposure to maternal smoking was associated with a reduction in FEV1 and FEF25-75 in males (regression coefficient, -0.16; 95% CI, -0.30 to -0.02), after accounting for maternal smoking after pregnancy. At least part of the effect of in utero smoking on young adults' lung function was explained by the child's birth weight and subsequent asthma.Conclusions: Adverse effects of antenatal smoking on development of airway growth may persist into early adulthood. Gender differences noted in this longitudinal cohort need to be explored further.