First experimental results of gated proton imaging using x-ray fluoroscopy to detect a fiducial marker
First experimental results of gated proton imaging using x-ray fluoroscopy to detect a fiducial marker
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使用 X 射线透视检测基准标记的门控质子成像的第一个实验结果
DOI：
10.1088/1361-6560/ac212b
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发表时间：
2021
影响因子：
3.5
通讯作者：
Matsuura Taeko
中科院分区：
文献类型：
--
作者：
Tanaka Sodai;Miyamoto Naoki;Matsuo Yuto;Yoshimura Takaaki;Takao Seishin;Matsuura Taeko
越来越多的质子成像研究正在进行，以准确确定质子治疗计划中的质子范围。然而，目前还没有质子成像系统可以处理运动伪影。本研究开发了一种门控质子成像系统，并首次获得了运动物体无运动伪影的质子放射成像（pRG）实验结果。介绍了一种利用双x射线透视检测球形金基准标记的运动管理系统，并根据物体的运动对质子束进行了门控。为了证明门控质子成像系统的性能，实验获得了运动幻影的门控pRG图像，运动伪影明显减弱。同时，针对本文开发的新型门控系统，对导致图像退化的因素进行了评价，确定了影响图像退化的主要因素是根据实际标记位置产生的理想门控信号与实际门控信号之间的延迟时间（最大延迟时间为93 ms）。由于时间结构的合理设置，质子成像系统和质子束辐照的延迟所造成的恶化可能性很小。
Increasing numbers of proton imaging research studies are being conducted for accurate proton range determination in proton therapy treatment planning. However, there is no proton imaging system that deals with motion artifacts. In this study, a gated proton imaging system was developed and the first experimental results of proton radiography (pRG) were obtained for a moving object without motion artifacts. A motion management system using dual x-ray fluoroscopy for detecting a spherical gold fiducial marker was introduced and the proton beam was gated in accordance with the motion of the object. To demonstrate the performance of the gated proton imaging system, gated pRG images of a moving phantom were acquired experimentally, and the motion artifacts clearly were diminished. Also, the factors causing image deteriorations were evaluated focusing on the new gating system developed here, and the main factor was identified as the latency (with a maximum value of 93 ms) between the ideal gating signal according to the actual marker position and the actual gating signal. The possible deterioration due to the latency of the proton imaging system and proton beam irradiation was small owing to appropriate setting of the time structure.