Hepatitis C Virus Core Mutations Associated with False-Negative Serological Results for Genotype 3a Core Antigen.
Hepatitis C Virus Core Mutations Associated with False-Negative Serological Results for Genotype 3a Core Antigen.
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DOI：
10.1128/jcm.01062-15
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发表时间：
2015-08
影响因子：
9.4
通讯作者：
De Gascun C
中科院分区：
文献类型：
--
作者：
Nguyen LT;Dunford L;Freitas I;Holder P;Nguyen LA;O'Gorman J;Connell J;Carr M;Hall W;De Gascun C
Genetic characterization of the genotype 3a (GT3a) hepatitis C virus (HCV) core region from HCV core antigen (HCVcAg)-negative/RNA-positive cases and HCVcAg-positive/RNA-positive controls identified significant associations between the substitutions A48T and T49A/P and failure to detect HCVcAg (P < 0.05). Polymorphisms at residues 48 and 49 in the core protein are present across all major epidemic and endemic GTs. These findings have implications for HCV diagnosis, particularly in low-income regions in which GT3a HCV is endemic.
