It's not too late: the onset of the frontocentral P3 indexes successful response inhibition in the stop-signal paradigm.
It's not too late: the onset of the frontocentral P3 indexes successful response inhibition in the stop-signal paradigm.
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DOI：
10.1111/psyp.12374
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发表时间：
2015-04
期刊：
影响因子：
3.7
通讯作者：
Aron AR
中科院分区：
文献类型：
--
作者：
Wessel JR;Aron AR
前额-中枢P3 ERP被认为是反应抑制的神经标记。然而，这种关联是有争议的：一些人认为P3潜伏期相对于动作停止的时间（停止信号反应时间；SSRT）来说太晚了，无法反映反应抑制。我们测试了P3发作潜伏期是否是反应抑制的标志，以及它是否与神经计算模型预测的时间一致。我们测量了62名参与者在停止信号任务期间的脑电图，并采用独立分量分析和排列统计来测量每个参与者的P3发作。我们发现，当停止成功时，P3的发作潜伏期更短，它与SSRT高度相关，并且与所声称的抑制过程的时间（SSRT结束时）一致。这些结果表明，P3开始潜伏期作为反应抑制过程的非侵入性、时间上精确的神经标记物的效用。
The fronto-central P3 ERP has been proposed as a neural marker of response inhibition. However, this association is disputed: some argue that P3 latency is too late relative to the timing of action-stopping (stop-signal reaction time; SSRT) to index response inhibition. We tested whether P3 onset latency is a marker of response inhibition, and whether it coincides with the timing predicted by neurocomputational models. We measured EEG in 62 participants during the stop-signal task, and used independent component analysis and permutation statistics to measure the P3 onset in each participant. We show that P3 onset latency is shorter when stopping is successful, that it is highly correlated with SSRT, and that it coincides with the purported timing of the inhibition process (towards the end of SSRT). These results demonstrate the utility of P3 onset latency as a non-invasive, temporally precise neural marker of the response inhibition process.