Reduced midbrain serotonin transporter availability in drug-naive patients with depression measured by SERT-specific [123I] nor-β-CIT SPECT imaging
Reduced midbrain serotonin transporter availability in drug-naive patients with depression measured by SERT-specific [123I] nor-β-CIT SPECT imaging
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DOI：
10.1016/j.pscychresns.2006.08.001
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发表时间：
2007-02-28
影响因子：
2.3
通讯作者：
Lehtonen, Johannes
中科院分区：
文献类型：
--
作者：
Joensuu, Mikko;Tolmunen, Tommi;Lehtonen, Johannes
早期的研究结果表明，严重抑郁症患者5-羟色胺转运体(SERT)的可获得性改变。与以前的研究相比，我们用更多的5-羟色胺特异性配体和更多的患者检测了SERT密度。以[I-123]Nor-β-CIT为配体，对29例未服用抗抑郁药物的重度抑郁障碍(MDD)患者和19例年龄、性别匹配的健康对照进行了SPECT研究。与对照组相比，患者中脑区的结合电位显著降低(-10%)。未发现与抑郁严重程度相关。这些发现表明抑郁症患者中脑区SERT的可用性降低，而且患者和对照组的个体间差异都很大。(C)2006爱思唯尔爱尔兰有限公司。保留所有权利。
Earlier results have indicated that serotonin transporter (SERT) availability is altered in major depression. We examined SERT density with a more serotonin-specific ligand and with a larger number of patients than in previous studies. Twenty-nine antidepressant-naive patients with major depressive disorder (MDD) and 19 healthy age- and sex-matched controls were studied with SPECT using [I-123] nor-beta-CIT as a ligand. The patients had a significantly lower (- 10%) binding potential in the midbrain region than controls. No correlation with depression severity was found. These findings indicate that SERT availability in the midbrain area is reduced in depression, and that interindividual variation is considerable in both patients and controls. (c) 2006 Elsevier Ireland Ltd. All rights reserved.