NSAID-Associated Small Intestinal Injury: An Overview From Animal Model Development to Pathogenesis, Treatment, and Prevention.
NSAID-Associated Small Intestinal Injury: An Overview From Animal Model Development to Pathogenesis, Treatment, and Prevention.
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NSAID 相关小肠损伤：从动物模型开发到发病机制、治疗和预防的概述
DOI：
10.3389/fphar.2022.818877
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发表时间：
2022
影响因子：
5.6
通讯作者：
Liao J
中科院分区：
文献类型：
--
作者：
Zhang M;Xia F;Xia S;Zhou W;Zhang Y;Han X;Zhao K;Feng L;Dong R;Tian D;Yu Y;Liao J
随着非甾体类抗炎药（NSAIDs）的广泛应用，其胃肠道副作用已成为紧迫的健康负担。目前对上消化道损伤有完善的预防措施，但对下消化道损伤缺乏有效的防御措施。根据以往的大量动物实验，多种NSAIDs已被证明可在体内引起小肠粘膜损伤。本文综述了各种NSAIDs的给药剂量、给药方法、粘膜损伤部位、炎症部位形态学特征的描述性数据。还对涉及 NSAID 相关肠病的细胞、细胞因子、受体和配体、途径、酶抑制、细菌、肠肝循环、氧化应激和其他潜在致病因素进行了综述。我们指出了现阶段药物模型的局限性，同时也很高兴地发现化学修饰的 NSAIDs、饮食疗法和许多天然产物对抗肠粘膜损伤的应用前景。
With the wide application of non-steroidal anti-inflammatory drugs (NSAIDs), their gastrointestinal side effects are an urgent health burden. There are currently sound preventive measures for upper gastrointestinal injury, however, there is a lack of effective defense against lower gastrointestinal damage. According to a large number of previous animal experiments, a variety of NSAIDs have been demonstrated to induce small intestinal mucosal injury in vivo. This article reviews the descriptive data on the administration dose, administration method, mucosal injury site, and morphological characteristics of inflammatory sites of various NSAIDs. The cells, cytokines, receptors and ligands, pathways, enzyme inhibition, bacteria, enterohepatic circulation, oxidative stress, and other potential pathogenic factors involved in NSAID-associated enteropathy are also reviewed. We point out the limitations of drug modeling at this stage and are also pleased to discover the application prospects of chemically modified NSAIDs, dietary therapy, and many natural products against intestinal mucosal injury.
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影响因子：
5.6
作者：
Ashraf Z;Alamgeer;Rasool R;Hassan M;Ahsan H;Afzal S;Afzal K;Cho H;Kim SJ
通讯作者：
Kim SJ
影响因子：
3.2
作者：
Ryu B;Son MY;Jung KB;Kim U;Kim J;Kwon O;Son YS;Jung CR;Park JH;Kim CY
通讯作者：
Kim CY
通过促进体内和体外自噬，来自柑橘的纯总类黄酮可以预防非甾体类抗炎药诱导的小肠损伤。
影响因子：
5.6
作者：
Chen S;Jiang J;Chao G;Hong X;Cao H;Zhang S
通讯作者：
Zhang S
影响因子：
4.4
作者：
Chung, Whasun O.;An, Jonathan Y.;Yin, Lei;Hacker, Beth M.;Rohani, Maryam G.;Dommisch, Henrik;DiJulio, Dennis H.
通讯作者：
DiJulio, Dennis H.
影响因子：
3.5
作者：
Buchholz BM;Bauer AJ
通讯作者：
Bauer AJ