Insular cortex lesions alter baroreceptor sensitivity in the urethane-anesthetized rat
Insular cortex lesions alter baroreceptor sensitivity in the urethane-anesthetized rat
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DOI：
10.1016/s0006-8993(98)00996-2
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发表时间：
1998-11-30
期刊：
影响因子：
2.9
通讯作者：
Oppenheimer, SM
中科院分区：
文献类型：
--
作者：
Zhang, ZH;Rashba, S;Oppenheimer, SM
心血管的代表性已被证明在岛叶皮质和偏侧化已被推断。在这项研究中，压力感受器增益进行了研究，在全身注射加压剂苯肾上腺素（PE）和降压剂硝普钠（SNP）在57只麻醉，雄性Sprague-Dawley大鼠之前和之后的单一损伤放置。病变主要局限于前额叶（左或右）或邻近皮质，对压力感受器增益没有显着影响。然而，左后岛叶损伤显著增加压力感受器增益（p < 0.0001），而右后岛叶损伤对压力感受器增益没有影响，尽管在损伤放置后心率和血压都显著增加（p < 0.05）。这些数据表明：（2）左岛叶皮质可能主要与副交感神经的心脏调节有关。相反，右后岛叶皮质可以调节心脏和血管交感神经紧张，已经建议在其他物种。(C)1998年由Elsevier Science B. V.出版，版权所有。
Cardiovascular representation has been demonstrated within the insular cortex and lateralization has been previously inferred. In this study, baroreceptor gain was investigated in response to the systemic injection of the presser agent phenylephrine (PE) and the depressor agent sodium nitroprusside (SNP) in 57 urethane-anesthetized, male Sprague-Dawley rats before and after single lesion placement. Lesions mainly confined to the anterior insula (left or right) or the adjacent cortex were without significant effect on baroreceptor gain. Left posterior insular lesions, however, significantly increased baroreceptor gain (p < 0.0001) whereas right posterior insular lesions had no effect on baroreceptor gain although heart rate and blood pressure were both significantly increased after lesion placement (p < 0.05). These data suggest that: (1) the posterior insula land not surrounding cortex or anterior insula) is primarily involved in cardiovascular control; (2) the left insular cortex may be chiefly concerned with parasympathetic cardiac regulation. Conversely, the right posterior insular cortex may regulate both cardiac and vasomotor sympathetic tone, as has been suggested in other species. (C) 1998 Published by Elsevier Science B.V. All rights reserved.