Expression of DNAM-1 (CD226) on inflammatory monocytes
Expression of DNAM-1 (CD226) on inflammatory monocytes
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DOI：
10.1016/j.molimm.2015.11.009
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发表时间：
2016-01-01
影响因子：
3.6
通讯作者：
Shibuya, Kazuko
中科院分区：
文献类型：
--
作者：
Anh Van Vo;Takenaka, Eri;Shibuya, Kazuko
DNAM-1是NK细胞和T细胞上表达的活化受体，并且在这些细胞针对靶细胞的细胞毒性中起重要作用。虽然DNAM-1在T细胞和NK细胞功能中的作用已经得到了很好的研究，但DNAM-1在髓样细胞上的表达和功能尚未完全了解。在这项研究中，我们研究了小鼠外周血单核细胞亚群上DNAM-1的表达，发现只有炎性单核细胞（iMos），而不是巡逻单核细胞（pMos），表达高水平的DNAM-1。此外，我们发现DNAM-1在人中也在iMos上而不是pMos上高度表达。此外，我们发现炎症单核细胞上的DNAM-1参与了细胞与表达CD 155的细胞的粘附。因此，我们认为炎症单核细胞上DNAM-1的表达在进化上是保守的，并作为血液炎症单核细胞上的粘附分子。(C)2015爱思唯尔有限公司版权所有。
DNAM-1 is an activating receptor expressed on NK cells and T cells and plays an important role in cytotoxicity of these cells against target cells. Although the role of DNAM-1 in the function of T cells and NK cells has been well studied, the expression and function of DNAM-1 on myeloid cells have been incompletely understood. In this study, we investigated expression of DNAM-1 on monocyte subsets in mouse peripheral blood and found that only inflammatory monocytes (iMos), but not patrolling monocytes (pMos), expressed high levels of DNAM-1. In addition, we found that DNAM-1 was highly expressed on iMos, rather than pMos, also in human. Furthermore, we found that DNAM-1 on inflammatory monocytes was involved in cell adhesion to CD155-expressing cells. Therefore, we propose that expression of DNAM-1 on inflammatory monocytes are evolutionally conserved and act as an adhesion molecule on blood inflammatory monocytes. (C) 2015 Elsevier Ltd. All rights reserved.