NEUROTOXICITY INDUCED BY EXPOSURE TO TOLUENE - AN ELECTROPHYSIOLOGIC STUDY
NEUROTOXICITY INDUCED BY EXPOSURE TO TOLUENE - AN ELECTROPHYSIOLOGIC STUDY
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DOI：
10.1007/bf00517943
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发表时间：
1993-02-01
影响因子：
3
通讯作者：
BRECCIAROLI, R
中科院分区：
文献类型：
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作者：
ABBATE, C;GIORGIANNI, C;BRECCIAROLI, R
本研究的目的是借助电生理学技术评估一组轮转凹版印刷工人因接触甲苯而引起的听觉神经系统的变化。我们从 300 名表面健康但因专业原因接触甲苯的工人中，选出了 40 名听力正常的工人作为样本。他们接受了脑干听觉诱发电位技术研究的适应性测试，每秒重复 11 次和 90 次刺激。结果与一组同龄但未专业接触溶剂的工人的结果进行了比较。我们的研究表明，接触甲苯能够在 11 次和 90 次刺激重复下引起电反应发生统计上显着的变化。这种改变可以解释为甲苯暴露引起的生理刺激传导机制的改变，即使没有任何神经病的临床症状。此外，可以在整个听觉系统（从外周受体到脑干核）的电反应中观察到这种改变。
The object of the present study was to evaluate, with the aid of electrophysiologic techniques, the alterations induced in the auditory nervous system by exposure to toluene in a group of rotogravure workers. From 300 workers who were apparently in good health but were professionally exposed to toluene, we selected a sample of 40 workers of normal hearing ability. They were examined with an adaptation test studied by the brainstem auditory evoked potential technique with 11 and 90 stimulus repetitions a second. The results were compared with those in a group of workers of the same age but not professionally exposed to solvents. Our study demonstrates that exposure to toluene is able to induce a statistically significant alteration in the electric responses with both 11 and 90 stimuli repetitions. This alteration can be explained as a toluene exposure-induced modification, of physiologic stimulus conduction mechanisms, even in the absence of any clinical sign of neuropathy. Furthermore, such a modification could be observed in the electric responses of the entire auditory system, from peripheral receptors to brainstem nuclei.