Does genetic heterogeneity account for the divergent risk of type 2 diabetes in South Asian and white European populations?
Does genetic heterogeneity account for the divergent risk of type 2 diabetes in South Asian and white European populations?
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DOI：
10.1007/s00125-014-3354-1
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发表时间：
2014-11
期刊：
影响因子：
8.2
通讯作者：
Anand, Sonia S.
中科院分区：
文献类型：
--
作者：
Sohani, Zahra N.;Deng, Wei Q.;Pare, Guillaume;Meyre, David;Gerstein, Hertzel C.;Anand, Sonia S.
南亚人患 2 型糖尿病的可能性是欧洲白人的四倍。据推测，较高的患病率是由于较大的遗传风险所致。为了评估这一假设，我们：（1）系统回顾了南亚人易患 2 型糖尿病的单核苷酸多态性（SNP）文献； (2) 比较南亚人和欧洲白人之间的风险估计、风险等位基因和易感 SNP 的风险等位基因频率； (3) 测试了从南亚人中发现的新 SNP 与欧洲白人的关联。检索了 MEDLINE、Embase、护理和联合健康文献累积索引 (CINAHL) 和 Cochrane 注册中心，以查找与南亚人 2 型糖尿病相关的遗传变异研究。将南亚人中常见和新型双等位基因 SNP 的荟萃分析估计值与糖尿病遗传学复制和荟萃分析 (DIAGRAM) 联盟的欧洲白人进行了比较。使用基因型评分评估易感 SNP 造成的人群负担。荟萃分析后，来自 21 个位点的 24 个 SNP 与南亚人的 2 型糖尿病相关。大多数 SNP 会使每个风险等位基因的患病几率增加 15-35%。从南亚人和欧洲白人共有的 SNP 来看，南亚人和欧洲白人之间的风险估计似乎不存在实质性差异，而且人口负担也没有差异。 24 个中的 8 个是南亚全基因组关联研究中发现的新 SNP，其中一些显示与欧洲白人中的 2 型糖尿病名义上存在关联。根据目前的文献，没有强有力的证据表明南亚人比欧洲白人具有更大的 2 型糖尿病遗传风险。本文的在线版本 (doi:10.1007/s00125-014-3354-1) 包含经过同行评审但未经编辑的补充材料，可供授权用户使用。
South Asians are up to four times more likely to develop type 2 diabetes than white Europeans. It is postulated that the higher prevalence results from greater genetic risk. To evaluate this hypothesis, we: (1) systematically reviewed the literature for single nucleotide polymorphisms (SNPs) predisposing to type 2 diabetes in South Asians; (2) compared risk estimates, risk alleles and risk allele frequencies of predisposing SNPs between South Asians and white Europeans; and (3) tested the association of novel SNPs discovered from South Asians in white Europeans. MEDLINE, Embase, the Cumulative Index to Nursing and Allied Health Literature (CINAHL) and the Cochrane registry were searched for studies of genetic variants associated with type 2 diabetes in South Asians. Meta-analysis estimates for common and novel bi-allelic SNPs in South Asians were compared with white Europeans from the DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) consortium. The population burden from predisposing SNPs was assessed using a genotype score. Twenty-four SNPs from 21 loci were associated with type 2 diabetes in South Asians after meta-analysis. The majority of SNPs increase odds of the disorder by 15–35% per risk allele. No substantial differences appear to exist in risk estimates between South Asians and white Europeans from SNPs common to both groups, and the population burden also does not differ. Eight of the 24 are novel SNPs discovered from South Asian genome-wide association studies, some of which show nominal associations with type 2 diabetes in white Europeans. Based on current literature there is no strong evidence to indicate that South Asians possess a greater genetic risk of type 2 diabetes than white Europeans. The online version of this article (doi:10.1007/s00125-014-3354-1) contains peer-reviewed but unedited supplementary material, which is available to authorised users.
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影响因子：
7
作者：
Huedo-Medina, Tania B.;Sanchez-Meca, Julio;Botella, Juan
通讯作者：
Botella, Juan
DOI：
10.1186/1479-5868-9-150
发表时间：
2012-12-20
期刊：
The international journal of behavioral nutrition and physical activity
影响因子：
--
作者：
Babakus WS;Thompson JL
通讯作者：
Thompson JL
影响因子：
3.5
作者：
Anuradha, S.;Radha, V.;Mohan, V.
通讯作者：
Mohan, V.
影响因子：
5.8
作者：
Johnson, Andrew D.;Handsaker, Robert E.;de Bakker, Paul I. W.
通讯作者：
de Bakker, Paul I. W.
影响因子：
4.7
作者：
Humphries, Steve E.;Gable, David;Talmud, Philippa J.
通讯作者：
Talmud, Philippa J.