Wnt signalling: variety at the core
Wnt signalling: variety at the core
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DOI：
10.1242/jcs.03363
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发表时间：
2007-02-01
影响因子：
4
通讯作者：
Kavanagh, Claire Louise
中科院分区：
文献类型：
--
作者：
Hoppler, Stefan;Kavanagh, Claire Louise
Wnt/β-连环蛋白途径是动物中保守的细胞-细胞信号传导机制，其通过TCF/LEF DNA结合因子调节基因表达以协调许多细胞过程。脊椎动物通常有四个Tcf/Lef基因，通过选择性剪接和选择性启动子的使用产生多种TCF/LEF亚型。最近几个实验系统的证据表明，这种多样性的TCF/LEF因子在脊椎动物中介导胚胎发育，干细胞分化和相关疾病，如癌症的组织和阶段特异性Wnt调节功能是重要的。
The Wnt/beta-catenin pathway is a conserved cell-cell signalling mechanism in animals that regulates gene expression via TCF/LEF DNA-binding factors to coordinate many cellular processes. Vertebrates normally have four Tcf/Lef genes, which, through alternative splicing and alternative promoter use give rise to a variety of TCF/LEF isoforms. Recent evidence from several experimental systems suggests that this diversity of TCF/LEF factors is functionally important in vertebrates for mediating tissue- and stage-specific Wnt regulation in embryonic development, stem cell differentiation and associated diseases, such as cancer.