EARLY AND TRANSIENT EFFECTS OF NEUTRON-IRRADIATION ON DOPAMINE-RECEPTORS IN THE ADULT-RAT BRAIN
EARLY AND TRANSIENT EFFECTS OF NEUTRON-IRRADIATION ON DOPAMINE-RECEPTORS IN THE ADULT-RAT BRAIN
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DOI：
10.1016/0304-3940(93)90677-d
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发表时间：
1993-05-28
影响因子：
2.5
通讯作者：
FATOME, M
中科院分区：
文献类型：
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作者：
MARTIN, C;RUBIO, I;FATOME, M
本文通过多巴胺D_1、D_2受体结合实验，研究了中子-γ辐射的早期神经化学效应。结合的参数进行了研究，从纹状体粗制剂在不同的延迟（从2到72小时）照射后。在接触后，即使在亚致死剂量下，也观察到部位总数的早期和短暂增加。D1受体的这种“放射敏感性”高于D2受体。据推测，这些修改可能参与在受辐射的人观察到的早期神经植物综合征。
The early neurochemical effects of neutron-gamma radiation exposures were studied through ligand dopamine D1, D2 receptors binding experiments. The parameters of binding were investigated on crude preparations from striatum at different delays (from 2 to 72 hours) after irradiation. An early and transient increase in the total number of sites was seen after exposure, even at infra-lethal dose. This 'radiosensitivity' was higher for D1 than for D2 receptor. It is assumed that these modifications could participate in the early neuro-vegetative syndrome observed in irradiated persons.