Aromatic Azido-selective Reduction via the Staudinger Reaction Using Tri-n-butylphosphonium Tetrafluoroborate with Triethylamine
Aromatic Azido-selective Reduction via the Staudinger Reaction Using Tri-n-butylphosphonium Tetrafluoroborate with Triethylamine
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DOI：
10.1246/cl.161159
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发表时间：
2017-04-01
影响因子：
1.6
通讯作者：
Hosoya, Takamitsu
中科院分区：
文献类型：
--
作者：
Meguro, Tomohiro;Yoshida, Suguru;Hosoya, Takamitsu
报道了一种使用四氟硼酸三正丁基鏻与三乙胺在四氢呋喃水溶液中通过施陶丁格反应将芳香族叠氮化物还原为苯胺的有效方法。该方法能够对3-叠氮基-5-(叠氮甲基)苯衍生物进行芳香族叠氮选择性还原，从而有效地得到带有叠氮甲基的苯胺。
An efficient method for the reduction of aromatic azides to anilines via the Staudinger reaction using tri-n-butylphosphonium tetrafluoroborate with triethylamine in aqueous tetrahydrofuran solution is reported. The method enables the aromatic azido-selective reduction of 3-azido-5-(azidomethyl) benzene derivatives to efficiently afford anilines bearing an azidomethyl group.