LOCALIZED INVIVO PROTON SPECTROSCOPY OF THE BONE-MARROW IN PATIENTS WITH LEUKEMIA
LOCALIZED INVIVO PROTON SPECTROSCOPY OF THE BONE-MARROW IN PATIENTS WITH LEUKEMIA
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DOI：
10.1016/0730-725x(90)90014-s
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发表时间：
1990-01-01
影响因子：
2.5
通讯作者：
HENRIKSEN, O
中科院分区：
文献类型：
--
作者：
JENSEN, KE;JENSEN, M;HENRIKSEN, O
体积选择性磁共振 (MR) 质子能谱用于研究白血病和真性红细胞增多症患者的造血（髂骨）和脂肪骨髓（胫骨）。对骨髓光谱中“水”和“脂肪”共振的弛豫时间 T1 和 T2 进行选择性测量。诊断时对九名急性白血病患者和三名慢性白血病患者进行了检查。还检查了三名缓解期的急性白血病患者。其中五名白血病患者接受了与化疗相关的随访检查。采用相同方法对9名真性红细胞增多症患者和21名正常对照者进行检查并进行比较。所有患者在每次 MR 检查前均进行骨髓活检。与健康正常对照相比，诊断时白血病患者的髂骨髓光谱模式存在显着差异。与正常人相比，白血病患者的髂骨髓谱中“相对含水量”增加，这表明造血组织量增加，骨髓脂肪含量相应减少。与正常对照和真性红细胞增多症患者相比，白血病患者髂骨骨髓光谱中“水”共振的 T1 弛豫时间在诊断时显着延长。化疗诱导缓解后，白血病患者髂骨髓的光谱与正常光谱相似。四名白血病患者的胫骨骨髓光谱异常，一名患者在化疗期间胫骨骨髓出现早期变化，然后在髂骨骨髓中检测到任何重大变化。
Volume selective magnetic resonance (MR) proton spectroscopy was used to investigate the haemopoetic (iliac bone) and fatty bone marrow (tibia) in patients with leukemia and polycythaemia vera. Selective measurements of the relaxation times T1 and T2 for the "water" and "fat" resonances in the bone marrow spectra were performed. Nine patients with acute leukemia and three patients with chronic leukemia were examined at diagnosis. Three patients with acute leukemia in remission were also examined. Five of the leukemic patients had follow-up examinations performed in relation to chemotherapeutic treatment. Nine patients with polycythaemia vera and 21 normal control subjects were examined with identical methods for comparison. All patients had bone marrow biopsies performed prior to every MR examination. Significant differences could be detected in the spectral patterns from iliac bone marrow in patients with leukemia at diagnosis compared to the healthy normal controls. The "relative water content" was increased in the iliac bone marrow spectra of the leukemic patients compared to the normal subjects, which indicates an increase in the amount of haemopoietic tissue and a corresponding decrease in marrow fat content. The T1 relaxation times of the "water" resonance in the spectra from the iliac bone marrow of the leukemic patients were significantly prolonged at diagnosis, compared to the normal controls and the patients with polycythaemia vera. After chemotherapeutic induction of remission, the spectra from the iliac bone marrow in the patients with leukemia resembled normal spectra. Four leukemic patients had abnormal spectra from the tibial bone marrow and one patient showed early changes in tibial marrow during chemotherapeutic treatment, before any major changes could be detected in the iliac bone marrow.