Changes of the directional brain networks related with brain plasticity in patients with long-term unilateral sensorineural hearing loss
Changes of the directional brain networks related with brain plasticity in patients with long-term unilateral sensorineural hearing loss
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DOI：
10.1016/j.neuroscience.2015.11.042
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发表时间：
2016-01
期刊：
影响因子：
3.3
通讯作者：
G. Zhang;Ming Yang;Bin Liu;Zhi-Chun Huang;Jing Li;Jing-ya Chen;Hua-Jun Chen;P. Zhang;Lijie Liu;Jian Wang;Jian Wang;G. Teng
中科院分区：
文献类型：
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作者：
G. Zhang;Ming Yang;Bin Liu;Zhi-Chun Huang;Jing Li;Jing-ya Chen;Hua-Jun Chen;P. Zhang;Lijie Liu;Jian Wang;Jian Wang;G. Teng
以前的研究经常报道，早期听觉剥夺或先天性耳聋有助于在听觉剥夺皮层的跨模态重组，这种跨模态重组限制了人工耳蜗的临床受益。然而，长期单侧感音神经性听力损失（USNHL）患者的皮层重组研究结果不一致。获得性单耳耳聋和早期或先天性耳聋的听觉皮层是否存在类似的跨模态可塑性也不清楚。为了解决这一问题，我们构建了基于静息态功能磁共振熵连通性的方向性脑功能网络，并研究了网络的变化。34名长期USNHL患者和17名听力正常的患者参加了测试，所有USNHL患者都患有获得性耳聋。我们发现，某些大脑区域的感觉运动和视觉网络提出了增强的同步输出熵连接与左初级听觉皮层在左长期USNHL的个人相比，正常听力的个人。特别是，左USNHL比右USNHL表现出更显著的熵连通性变化。在右侧USNHL中未观察到显著的塑性变化。我们的研究结果表明，左USNHL患者的左初级听觉皮层（非听觉剥夺皮层）已重组的视觉和感觉运动模式，通过跨模态可塑性。此外，跨通道重组也改变了定向脑功能网络。左侧听觉剥夺和右侧听觉剥夺对人脑的影响是不同的。
Previous studies often report that early auditory deprivation or congenital deafness contributes to cross-modal reorganization in the auditory-deprived cortex, and this cross-modal reorganization limits clinical benefit from cochlear prosthetics. However, there are inconsistencies among study results on cortical reorganization in those subjects with long-term unilateral sensorineural hearing loss (USNHL). It is also unclear whether there exists a similar cross-modal plasticity of the auditory cortex for acquired monaural deafness and early or congenital deafness. To address this issue, we constructed the directional brain functional networks based on entropy connectivity of resting-state functional MRI and researched changes of the networks. Thirty-four long-term USNHL individuals and seventeen normally hearing individuals participated in the test, and all USNHL patients had acquired deafness. We found that certain brain regions of the sensorimotor and visual networks presented enhanced synchronous output entropy connectivity with the left primary auditory cortex in the left long-term USNHL individuals as compared with normally hearing individuals. Especially, the left USNHL showed more significant changes of entropy connectivity than the right USNHL. No significant plastic changes were observed in the right USNHL. Our results indicate that the left primary auditory cortex (non-auditory-deprived cortex) in patients with left USNHL has been reorganized by visual and sensorimotor modalities through cross-modal plasticity. Furthermore, the cross-modal reorganization also alters the directional brain functional networks. The auditory deprivation from the left or right side generates different influences on the human brain.