Coral Comparative Genomics Reveal Expanded Hox Cluster in the Cnidarian-Bilaterian Ancestor
Coral Comparative Genomics Reveal Expanded Hox Cluster in the Cnidarian-Bilaterian Ancestor
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DOI：
10.1093/icb/ics098
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发表时间：
2012-12-01
影响因子：
2.6
通讯作者：
Martindale, Mark Q.
中科院分区：
文献类型：
--
作者：
DuBuc, Timothy Q.;Ryan, Joseph F.;Martindale, Mark Q.
Hox基因簇的关键发育作用是在原口动物和后口动物的最后一个共同祖先之前确立的，该基因簇随后的进化在现存两侧对称动物所表现出的形态多样性中发挥了重要作用。尽管对刺胞动物 Hox 基因进行了 20 年的研究，但刺胞动物-两侧对称动物祖先 Hox 簇的性质仍不清楚。为了进一步阐明这个关键的系统发育节点，我们对最近测序的鹿角珊瑚基因组的 Hox 簇进行了表征。 A. digitalifera 基因组包含两个前 Hox 基因（PG1 和 PG2），与 Eve 同源盒基因和 Anthox1A 基因相连，Anthox1A 基因被认为是后 Hox 基因或后/中央 Hox 基因。这些数据表明，刺胞动物-两侧对称动物祖先的Hox簇比之前认为的更广泛。结果与 Hox 簇上存在的一组古老约束一致，并强调了纳入广泛的动物物种来重建关键祖先节点的重要性。
The key developmental role of the Hox cluster of genes was established prior to the last common ancestor of protostomes and deuterostomes and the subsequent evolution of this cluster has played a major role in the morphological diversity exhibited in extant bilaterians. Despite 20 years of research into cnidarian Hox genes, the nature of the cnidarian-bilaterian ancestral Hox cluster remains unclear. In an attempt to further elucidate this critical phylogenetic node, we have characterized the Hox cluster of the recently sequenced Acropora digitifera genome. The A. digitifera genome contains two anterior Hox genes (PG1 and PG2) linked to an Eve homeobox gene and an Anthox1A gene, which is thought to be either a posterior or posterior/central Hox gene. These data show that the Hox cluster of the cnidarian-bilaterian ancestor was more extensive than previously thought. The results are congruent with the existence of an ancient set of constraints on the Hox cluster and reinforce the importance of incorporating a wide range of animal species to reconstruct critical ancestral nodes.