The contractile effect of fedotozine on guinea pig isolated intestinal cells is not mediated by kappa opioid receptors
The contractile effect of fedotozine on guinea pig isolated intestinal cells is not mediated by kappa opioid receptors
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DOI：
10.1159/000028210
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发表时间：
1998-06-01
期刊：
影响因子：
3.1
通讯作者：
Bertaccini, G
中科院分区：
文献类型：
--
作者：
Coruzzi, G;Morini, G;Bertaccini, G
最近被描述为外周kappa阿片受体激动剂的复方非多津在豚鼠回肠纵肌层分离的平滑肌细胞上进行了试验，并与选择性kappa受体激动剂化合物U-50488进行了比较。非度托津(1nmol/L-1mU/L)可引起肠细胞呈浓度依赖性收缩，其最大收缩长度与乙酰胆碱无明显差异。Kappa激动剂U-50488(0.1pmo1/L-100nmo1/L)无作用。纳洛酮(0.1-1mU·mol/L)对非多津的收缩作用无明显影响。这些结果表明，苯妥秦对豚鼠回肠平滑肌细胞具有直接兴奋作用，而不是通过激活kappa阿片受体介导的。
The compound fedotozine, recently described as a peripheral kappa opioid receptor agonist, was tested on smooth muscle cells isolated from the longitudinal muscle layer of the guinea pig ileum, in comparison with the selective kappa receptor agonist, compound U-50488. Fedotozine (1 nmol/l - 1 mu mol/l) caused a concentration-dependent contraction of intestinal cells, with a maximum decrease in cell length not significantly different from that caused by acetylcholine. The kappa agonist U-50488 (0.1 pmol/l-100 nmol/l) was without effect. The contractile effect of fedotozine was not significantly modified by naloxone (0.1-1 mu mol/l). These results indicate that fedotozine can have direct excitatory effects on intestinal smooth muscle cells from the guinea pig ileum not mediated by activation of kappa opioid receptors.