Immunologic priming with recombinant hepatitis A virus capsid proteins produced in Escherichia coli
Immunologic priming with recombinant hepatitis A virus capsid proteins produced in Escherichia coli
复制标题
使用大肠杆菌产生的重组甲型肝炎病毒衣壳蛋白进行免疫启动
作者：
T. Powdrill;J. Johnston
甲型肝炎病毒衣壳蛋白（VP0、VP3和VP1）已在大肠杆菌中合成，用于抗原性和免疫原性分析。用这些单独的重组衣壳蛋白免疫的兔在随后用亚免疫原性剂量的全病毒攻击时产生快速中和抗体应答。
Hepatitis A virus capsid proteins (VP0, VP3, and VP1) have been synthesized in Escherichia coli for use in antigenic and immunogenic analyses. Rabbits immunized with each of these individual recombinant capsid proteins developed a rapid neutralizing antibody response when subsequently challenged with a subimmunogenic dose of whole virus.