Intensive lifestyle changes may affect the progression of prostate cancer
Intensive lifestyle changes may affect the progression of prostate cancer
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DOI：
10.1097/01.ju.0000169487.49018.73
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发表时间：
2005-09-01
影响因子：
6.6
通讯作者：
Carroll, PR
中科院分区：
文献类型：
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作者：
Ornish, D;Weidner, G;Carroll, PR
目的：前列腺癌患者经常被建议改变饮食和生活方式，尽管这些改变的影响还没有很好的记录。因此，我们评估了综合生活方式改变对早期前列腺癌患者1年后前列腺特异性抗原(PSA)、治疗趋势和血清刺激的LNCaP细胞生长的影响。材料和方法：患者招募仅限于选择不接受任何常规治疗的男性，这提供了一个不干预的随机对照组的不同寻常的机会，以避免放疗、手术或雄激素剥夺治疗等干预措施的混杂效果。将93例血清PSA4~10 ng/ml，癌症Gleason评分<7分的志愿者随机分为研究组和对照组，分别要求患者进行全面的生活方式改变和常规护理对照组。结果：实验组患者中无一例接受常规治疗，而对照组中有6例患者因PSA升高和(或)磁共振成像显示疾病进展而接受常规治疗。实验组PSA值下降4%，对照组上升6%(P=0.016)。实验组血清对LNCaP前列腺癌细胞的生长抑制率为对照组的8倍(70%比9%，P
Purpose: Men with prostate cancer are often advised to make changes in diet and lifestyle, although the impact of these changes has not been well documented. Therefore, we evaluated the effects of comprehensive lifestyle changes on prostate specific antigen (PSA), treatment trends and serum stimulated LNCaP cell growth in men with early, biopsy proven prostate cancer after 1 year.Materials and Methods: Patient recruitment was limited to men who had chosen not to undergo any conventional treatment, which provided an unusual opportunity to have a nonintervention randomized control group to avoid the confounding effects of interventions such as radiation, surgery or androgen deprivation therapy. A total of 93 volunteers with serum PSA 4 to 10 ng/ml and cancer Gleason scores less than 7 were randomly assigned to an experimental group that was asked to make comprehensive lifestyle changes or to a usual care control group.Results: None of the experimental group patients but 6 control patients underwent conventional treatment due to an increase in PSA and/or progression of disease on magnetic resonance imaging. PSA decreased 4% in the experimental group but increased 6% in the control group (p = 0.016). The growth of LNCaP prostate cancer cells (American Type Culture Collection, Manassas, Virginia) was inhibited almost 8 times more by serum from the experimental than from the control group (70% vs 9%, p