Radioprotective and In-Vitro Cytotoxic Sapogenin from Euphorbia neriifolia (Euphorbiaceae) Leaf
Radioprotective and In-Vitro Cytotoxic Sapogenin from Euphorbia neriifolia (Euphorbiaceae) Leaf
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DOI：
10.4314/tjpr.v8i6.49399
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发表时间：
2010-01
影响因子：
0.6
通讯作者：
P. Bigoniya;A. Rana
中科院分区：
文献类型：
--
作者：
P. Bigoniya;A. Rana
Purpose: Euphorbia neriifolia Linn. (Euphorbiaceae) plant is traditionally used in the treatment of abdominal troubles, bronchitis, tumours, leucoderma, piles, inflammation, and enlargement of spleen. The objective of this study was to evaluate the antioxidant and anticancer activities of a sapogenin isolate of this plant. Methods: Euphol was isolated as a major constituent from the triterpenoidal sapogenin fraction of E. neriifolia leaf. Its in-vitro antioxidant activity was evaluated by reducing power assay, 1,1 – diphenyl –2- picryl hydrazyl (DPPH) assay, as well as hydroxyl radical and superoxide radical scavenging activities. Radioprotective activity was assessed against radiation-induced chromosomal aberrations and cytotoxicity on murine F1 B16 melanoma. Results: The sapogenin exerted moderate antioxidant activity with highly significant (p E. neriifolia. Keywords : Euphorbia neriifolia ; Euphol; Sapogenin; Antioxidant; Radioprotective; Melanoma; Chromosomal aberration
