Effect of steroids on [18F]fluorodeoxyglucose uptake in an experimental tumour model
Effect of steroids on [18F]fluorodeoxyglucose uptake in an experimental tumour model
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DOI：
10.1097/01.mnm.0000126512.26835.27
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发表时间：
2004-07-01
影响因子：
1.5
通讯作者：
Tamaki, N
中科院分区：
文献类型：
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作者：
Zhao, S;Kuge, Y;Tamaki, N
背景众所周知，血糖水平影响肿瘤对2-[F-18]氟-2-脱氧-D-葡萄糖（FDG）的摄取。因此，类固醇对葡萄糖代谢的作用可能会改变血糖水平，并可能影响类固醇治疗患者肿瘤中FDG的摄取。为了澄清这一点，我们确定了类固醇对FDG摄取的影响，在肿瘤的大鼠模型中的恶性肿瘤。方法大鼠接种同种异体肝癌细胞（KDH-8）到左小腿肌肉。随机分为3组（每组5只）：（1）地塞米松（DEX）预处理组（0.8mg. kg（-1）体重，i.m.注射FDG前4 h静脉注射）;（2）泼尼松龙（PRE）预处理（8 mg（.）kg（-1）体重，i.m.静脉注射FDG前20小时注射）;和（3）对照（未治疗）组。静脉注射FDG后1小时测定组织中的放射性。FDG在肿瘤中的摄取表示为注射剂量的百分比每克组织后，归一化到动物的体重（%ID/g组织/kg体重）。结果DEX和PRE预处理显着增加血糖水平的128%和145%的控制值。DEX和PRE预处理对肿瘤中FDG摄取的水平没有显著影响（分别为对照值的90%和87%）（P=NS）。结论这些结果表明，尽管血糖水平略有升高，但类固醇预处理对肿瘤中FDG摄取没有影响。(C)2004年利平科特威廉姆斯威尔金斯。
Background It is well known that blood glucose level affects the uptake of 2-[F-18]fluoro-2-deoxy-D-glucose (FDG) in tumours. Thus, the action of steroids on glucose metabolism may alter blood glucose levels and may affect FDG uptake in tumours in patients treated with steroids. To clarify this point, we determined the effects of steroids on FDG uptake in tumours in a rat model of a malignant tumour.Methods Rats were inoculated with allogenic hepatoma cells (KDH-8) into the left calf muscle. They were fasted overnight and divided into three groups (n=5 in each group): (1) dexamethasone (DEX) pretreated (0.8 mg(.)kg(-1) body weight, i.m. injection 4 h before FDG i.v. injection); (2) prednisolone (PRE) pretreated (8 mg(.)kg(-1) body weight, i.m. injection 20 h before FDG i.v. injection); and (3) control (untreated) groups. Radioactivity in tissues was determined 1 h after i.v. injection of FDG. FDG uptake in the tumour was expressed as the percentage of injected dose per gram of tissue after normalization to animal's weight (%ID/g tissue/kg body weight).Results DEX and PRE pretreatments significantly increased the blood glucose levels to 128% and 145% of the control value. The levels of FDG uptake in the tumour were not significantly affected by DEX and PRE pretreatment (90% and 87% of the control value, respectively) (P=NS).Conclusions These results demonstrate that FDG uptake in the tumour was not affected by pretreatment with steroids, in spite of a slight elevation in blood glucose level. (C) 2004 Lippincott Williams Wilkins.