Combining transition metals and transient directing groups for C-H functionalizations.
Combining transition metals and transient directing groups for C-H functionalizations.
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DOI：
10.1039/c8ra03230k
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发表时间：
2018-05-25
期刊：
影响因子：
3.9
通讯作者：
Maiti, Debabrata
中科院分区：
文献类型：
--
作者：
Bhattacharya, Trisha;Pimparkar, Sandeep;Maiti, Debabrata
在合成化学领域，C-H键活化在过去几十年中一直是研究人员关注的焦点。虽然已经采用了不同的策略来化学触发未活化的C-H键，但过渡金属催化的导向基团（DG）辅助的C-H键活化是所有途径中探索最多的途径，因为其能够执行不同位点选择性功能变态。尽管其受欢迎，但繁琐的合成方法需要额外的步骤来安装DG和从靶底物去除DG，这降低了其功效。然而，用瞬时导向基团（tDG）代替导向基团在更大程度上降低了障碍，而不损害产物产率和选择性。在这份报告中，我们已经描绘了激烈的旅程的瞬态定向基团与三个（铑，钌，钯）普遍的第二行过渡金属。本文综述了三种主要的第二行过渡金属促进的瞬态导向基团辅助C-H官能化反应的重要进展。
In the domain of synthetic chemistry, C–H bond activation has always remained in the spotlight for researchers over the last few decades. Although different strategies have been employed to chemically trigger unactivated C–H bonds, transition metal catalyzed directing group (DG) aided C–H bond activation is the most explored pathway of all because of its ability to perform diverse site selective functional metamorphosis. Despite its popularity, tedious synthetic methodology requiring additional steps for the installation and removal of DGs from the target substrate diminishes its efficacy. However, replacement of directing groups by transient directing groups (tDGs) reduces the hurdle to a greater extent without compromising the product yield and selectivity. In this report we have depicted the intense journey of transient directing groups with three (Rh, Ru, and Pd) prevalent second row transition metals. This review is about the momentous evolution of transient directing group assisted C–H functionalizations promoted by three major second row transition metals.
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