Assignment of the Zona pellucida 3 receptor (Zp3r) gene to mouse chromosome 1E-F by fluorescence in situ hybridization and confirmation by genetic mapping.
Assignment of the Zona pellucida 3 receptor (Zp3r) gene to mouse chromosome 1E-F by fluorescence in situ hybridization and confirmation by genetic mapping.
复制标题
通过荧光原位杂交将透明带 3 受体 (Zp3r) 基因分配给小鼠染色体 1E-F，并通过遗传图谱进行确认。
DOI：
10.1159/000015346
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Martin-DeLeon,PA
中科院分区：
文献类型：
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作者：
Deng,X;Copeland,NG;Gilbert,DJ;Jenkins,NA;Martin-DeLeon,PA
本研究利用荧光原位杂交技术将透明质酸3受体（Zp3r）基因定位于小鼠1号染色体EF上，并通过遗传作图进行了验证。透明质酸3受体基因Zp3r编码精子受精蛋白Sp56，该蛋白对透明质酸具有特异性亲和力。Sp56定位于精子的背表面，属于由基因复制产生的蛋白质受体超家族，并且在结构上相似。该蛋白质具有种属特异性和组织特异性，在减数分裂后表达。
This article focuses on the assignment of the zona pellucida 3 receptor (Zp3r) gene to mouse chromosome 1 EF by fluorescence in situ hybridization and confirmation by genetic mapping. The zona pellucida 3 receptor gene, Zp3r, encodes the sperm fertilization protein, Sp56, which has a specific affinity for the zona pellucida. Sp56, which is localized to the dorsal surface of the sperm belongs to a superfamily of protein receptors that have arisen by gene duplication, and are structurally similar. The protein is species-restricted and tissue-specific with postmeiotic expression.