Haematophagous arthropod saliva and host defense system: a tale of tear and blood
Haematophagous arthropod saliva and host defense system: a tale of tear and blood
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DOI：
10.1590/s0001-37652005000400008
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发表时间：
2005-12-01
期刊：
影响因子：
--
通讯作者：
Barral-Netto, Manoel
中科院分区：
文献类型：
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作者：
Andrade, Bruno B.;Teixeira, Clarissa R.;Barral-Netto, Manoel
来自吸血节肢动物载体的唾液富含显示多种功能的分子，这些功能介导成功的血餐。它们不仅作为对抗宿主的止血、炎症和免疫反应的武器，而且作为病原体建立的重要工具。寄生虫、病毒和细菌利用病媒的武器进行了适应，以便于它们进入宿主。今天，许多唾液分子已被鉴定和表征为未来疫苗开发的新靶点。在这里，我们集中油流信息载体的唾液和分子负责修改宿主的止血和免疫反应，也关于他们在疾病传播中的作用。
The saliva from blood-feeding arthropod vectors is enriched with molecules that display diverse functions that mediate a successful blood meal. They function not only as weapons against host's haemostatic, inflammatory and immune responses but also as important tools to pathogen establishment. Parasites, virus and bacteria taking advantage of vectors' armament have adapted to facilitate their entry in the host. Today, many salivary molecules have been identified and characterized as new targets to the development of future vaccines. Here we focus oil current information on vector's saliva and the molecules responsible to modify host's hemostasis and immune response, also regarding their role in disease transmission.