Hypoglycaemic episodes and risk of dementia in diabetes mellitus: 7-year follow-up study
Hypoglycaemic episodes and risk of dementia in diabetes mellitus: 7-year follow-up study
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DOI：
10.1111/joim.12000
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发表时间：
2013-01-01
影响因子：
11.1
通讯作者：
Sheu, W. H. -H.
中科院分区：
文献类型：
--
作者：
Lin, C. -H.;Sheu, W. H. -H.
Lin C-H，Sheu WH-H（台中荣民总医院;台中荣民总医院;台中中山医科大学;台北国立阳明大学;台湾台中国立中兴大学）。糖尿病患者低血糖发作与痴呆风险：7年随访研究J Intern Med 2013; 273：102 - 110.目的研究有无低血糖发作史的2型糖尿病患者发生痴呆的风险。受试者和设置从台湾全民健康保险研究数据库中随机抽取100万名受试者。结果共有15名类似于404名糖尿病受试者，无痴呆病史，平均年龄64.2岁。约2%（n = 289）的受试者在3年内至少发生一次低血糖;这些受试者年龄较大，更可能是女性，与无低血糖的受试者相比，胰岛素使用率和合并症发生率也较高。在总共7年的随访期间（平均和中位随访时间分别为3.8和4.8年），1106例糖尿病患者（7.2%）发生痴呆。与无低血糖发作的受试者[11.1/1000人-年（95% CI 10.311.8）]相比，有[29.9/1000人-年（95% CI 22.139.2）]低血糖发作的糖尿病受试者的痴呆发生率更高。痴呆的粗率比（RR）和年龄及性别校正的RR值为2.76（95%CI 2.063.70，P类似于
Lin C-H, Sheu WH-H (Taichung Veterans General Hospital; Taichung Veterans General Hospital; Chung Shan Medical University, Taichung; National Yang-Ming University, Taipei; and National Chung-Hsing University, Taichung, Taiwan). Hypoglycaemic episodes and risk of dementia in diabetes mellitus: 7-year follow-up study. J Intern Med 2013; 273: 102-110. Objective We investigated the risk of dementia in patients with type 2 diabetes with or without prior hypoglycaemic episodes. Subjects and Setting One million subjects randomly selected from the National Health Insurance Research Database, Taiwan. Results A total of 15 similar to 404 diabetic subjects without prior dementia and a mean age of 64.2 similar to years were enrolled in the study. About 2% (n similar to=similar to 289) of participants had at least one episode of hypoglycaemia in a 3-year period; these subjects were older and more likely to be women and also had higher rates of insulin use and comorbidities compared to those without hypoglycaemia. During a total of 7 similar to years of follow-up (mean and median follow-up, 3.8 and 4.8 similar to years, respectively), 1106 patients with diabetes (7.2%) developed dementia. The incidence rate of dementia was higher in diabetic subjects with [29.9 per 1000 person-years (95% CI 22.139.2)] compared to those without [11.1 per 1000 person-years (95% CI 10.311.8)] hypoglycaemic episodes. The crude rate ratio (RR) and age- and gender-adjusted RR values for dementia were 2.76 (95% CI 2.063.70, P similar to