Human stem cell grafts as therapies for motor neuron disease
Human stem cell grafts as therapies for motor neuron disease
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DOI：
10.1517/14712598.8.2.137
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发表时间：
2008-02-01
影响因子：
4.6
通讯作者：
Yan, Jun
中科院分区：
文献类型：
--
作者：
Koliatsos, Vassilis E.;Xu, Leyan;Yan, Jun
干细胞移植是一种被广泛接受的治疗模块化器官疾病的方法，如心脏和内分泌胰腺，对于神经系统仍然是一个有争议的选择。然而，20世纪90年代在神经可塑性关键方面的历史进展，以及对神经细胞和系统在退行性和创伤性疾病中的选择性脆弱性的认识，要求对这种怀疑进行重新审视。先前营养因子治疗的成功和失败尤其具有启发性；从这个时代的许多经验教训可以创造性地吸收与疾病的动物模型干细胞移植的早期结果进行评估。干细胞移植到脊髓中，传统上是一项注定失败的事业，因为该区域缺乏神经原性和多次早期失败，随着作者实验室和其他地方最近的发现，特定类型的细胞和培养方法与生物学和功能结果的改善有关，干细胞移植再次变得有希望。
Stem cell transplantation, a widely accepted therapeutic approach to diseases of modular organs such as the heart and the endocrine pancreas, remains a controversial option for the nervous system. However, historical advances in the 1990s on key aspects of neural plasticity and the appreciation of the selective vulnerability of nerve cells and systems in degenerative and traumatic diseases require a re-examination of this scepticism. The successes and failures with prior trophic factor therapies are particularly enlightening; many lessons from this era can be creatively absorbed as the early outcomes with stem cell grafts in animal models of disease are evaluated. Stem cell grafting into spinal cord, traditionally a doomed enterprise because of lack of neurogenicity in this region and multiple early failures, is becoming promising again with recent findings from the authors' laboratory and elsewhere that specific types of cells and methods of culture are associated with much improved biological and functional outcomes.