Prenatal smoking exposure and asymmetric fetal growth restriction
Prenatal smoking exposure and asymmetric fetal growth restriction
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DOI：
10.1080/03014460802375596
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发表时间：
2008-01-01
影响因子：
1.7
通讯作者：
Brabin, Bernard J.
中科院分区：
文献类型：
--
作者：
Delpisheh, Ali;Brabin, Loretta;Brabin, Bernard J.
背景资料：产前吸烟暴露导致宫内胎儿生长受限（IUGR），尽管其对胎儿比例的影响尚不明确defined.Aim：本研究评估胎儿比例在胎儿宫内生长受限婴儿使用母亲唾液可替宁，以表明母亲吸烟暴露。英国利物浦妇女医院对不对称和对称IUGR婴儿以及非生长受限婴儿进行了一项病例对照研究。结果：共纳入白色孕妇270例，其中IUGR病例90例，对照组180例。胎儿发育不对称占52.2%。与对照组相比，不对称IUGR组（p = 0.002）的母体几何平均可替宁浓度高于对称IUGR组（p = 0.07）。母亲吸烟暴露与不对称IUGR独立相关（OR 2.4，95%CI，1.5-4.4，p
Background: Prenatal smoking exposure causes intrauterine fetal growth restriction ( IUGR), although its effects on fetal proportionality are less clearly defined.Aim: The present study assessed fetal proportionality in babies with IUGR using maternal salivary cotinine to indicate maternal smoking exposure.Subjects and methods: A case-control study at the Liverpool Women's Hospital, UK of babies with asymmetric and symmetric IUGR and non-growth restricted babies was carried out.Results: 270 white women including 90 IUGR cases and 180 controls were enrolled. Asymmetry presented in 52.2% of IUGR cases. Geometric mean maternal cotinine concentration was higher with asymmetric (p = 0.002) than symmetric IUGR (p = 0.07), when compared to controls. Maternal smoking exposure was independently associated with asymmetric IUGR (OR 2.4, 95% CI, 1.5-4.4, p