Zidovudine therapy is associated with an increased capacity of phytohemagglutinin-stimulated cells to express interleukin-2 receptors. Pittsburgh AIDS Clinical Trial Unit.
Zidovudine therapy is associated with an increased capacity of phytohemagglutinin-stimulated cells to express interleukin-2 receptors. Pittsburgh AIDS Clinical Trial Unit.
复制标题
齐多夫定治疗与植物血凝素刺激的细胞表达白细胞介素 2 受体的能力增加有关。
DOI：
10.1097/00002030-199105000-00003
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Ho,M
中科院分区：
文献类型：
--
作者：
McMahon,DK;Winkelstein,A;Armstrong,JA;Pazin,GJ;Hawk,H;Ho,M
艾滋病患者的齐多夫定治疗仅能暂时改善循环中的CD4+细胞数量和培养的淋巴细胞的体外功能活动。本研究旨在确定延长齐多夫定治疗是否能提高两项敏感的T细胞功能检测的反应性：植物血凝素(PHA)刺激的细胞形成T细胞集落的能力和它们表达生长因子白介素2(IL-2)受体的能力。经过20-60周的研究，接受治疗的患者在任何时间间隔内的集落形成都没有改善，即使在补充了外源性IL-2的平板中也是如此。然而，丝裂原刺激的T淋巴细胞表达IL-2受体(CD25)的能力显著增加。这种增强的表达主要是由于CD8+细胞亚群的激活。
Zidovudine therapy of AIDS patients has been shown to cause only transient improvements in the numbers of circulating CD4+ cells and the in vitro functional activities of cultured lymphocytes. The present studies were undertaken to determine whether prolonged zidovudine therapy enhanced reactivity in two sensitive assays of T-cell function: the ability of phytohemagglutinin (PHA)-stimulated cells to form T-cell colonies and their capacity to express receptors for the growth factor interleukin-2 (IL-2). Treated patients, studied over periods of 20–60 weeks, showed no improvement in colony formation at any time interval, even in plates supplemented with exogenous IL-2. However, mitogen-stimulated T lymphocytes showed a significant increase in the capacity to express IL-2 receptors (CD25). This enhanced expression resulted primarily from activation of the CD8+ cell subset.