Fourier analysis of sinusoidally driven thalamocortical relay neurons and a minimal integrate-and-fire-or-burst model
Fourier analysis of sinusoidally driven thalamocortical relay neurons and a minimal integrate-and-fire-or-burst model
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DOI：
10.1152/jn.2000.83.1.588
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发表时间：
2000-01-01
影响因子：
2.5
通讯作者：
Rinzel, J
中科院分区：
文献类型：
--
作者：
Smith, GD;Cox, CL;Rinzel, J
我们从猫丘脑切片制备的外侧膝状体核的中继神经元进行细胞内记录。我们测量了在紧张和突发发射模式正弦电流注入的反应，并对这些反应进行傅立叶分析。做个比较。我们构建了一个最小的“整合和激发或爆发”（IFB）神经元模型，其再现了中继细胞响应的显著特征。IFB模型的限制，以定量地适合我们的实验中继神经元的反应，包括傅立叶分析：在紧张和突发模式的响应的时间调谐，包括发现低通，有时宽带行为的紧张性放电和带通特性在突发，和一般更大的线性度的紧张性相比，在低频率的突发响应。在主音模式下，实验和理论响应都显示了从大量超谐波尖峰到3 Hz附近的锁相超谐波尖峰的频率依赖性过渡，然后是更高频率下的锁相次谐波尖峰。实验上还观察到了次谐波和超谐波脉冲响应。表征响应特性的“调谐”IFB模型导致洞察有关观察到的刺激依赖性的突发与紧张性反应模式在中继神经元。此外，IFB模型的简单性使其成为丘脑功能的大规模网络模拟的候选者。
We performed intracellular recordings of relay neurons from the lateral geniculate nucleus of a cat thalamic slice preparation. We measured responses during both tonic and burst firing modes to sinusoidal current injection and performed Fourier analysis on these responses. For comparison. we constructed a minimal "integrate-and-fire-or-burst" (IFB) neuron model that reproduces salient features of the relay cell responses. The IFB model is constrained to quantitatively fit our Fourier analysis of experimental relay neuron responses, including: the temporal tuning of the response in both tonic and burst modes, including a finding of low-pass and sometimes broadband behavior of tonic firing and band-pass characteristics during bursting, and the generally greater linearity of tonic compared with burst responses at low frequencies. In tonic mode, both experimental and theoretical responses display a frequency-dependent transition from massively superharmonic spiking to phase-locked superharmonic spiking near 3 Hz, followed by phase-locked subharmonic spiking at higher frequencies. Subharmonic and superharmonic burst responses also were observed experimentally. Characterizing the response properties of the "tuned" IFB model leads to insights regarding the observed stimulus dependence of burst versus tonic response mode in relay neurons. Furthermore the simplicity of the IFB model makes it a candidate for large scale network simulations of thalamic functioning.