Vaginal Glycogen, Not Estradiol, Is Associated With Vaginal Bacterial Community Composition in Black Adolescent Women.
Vaginal Glycogen, Not Estradiol, Is Associated With Vaginal Bacterial Community Composition in Black Adolescent Women.
复制标题
阴道糖原（而不是雌二醇）与黑人青春期女性的阴道细菌群落组成相关。
DOI：
10.1016/j.jadohealth.2019.01.010
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Forney,LarryJ
中科院分区：
文献类型：
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作者：
Nunn,KenettaL;Ridenhour,BenjaminJ;Chester,EmilyM;Vitzthum,VirginiaJ;Fortenberry,JDennis;Forney,LarryJ
PurposeThe目的本研究的目的是描述组成的阴道细菌群落在一个队列的黑人青少年妇女，并确定这些社区的物种组成如何与雌二醇，糖原，和stress.MethodsTwenty-one黑人青少年妇女进行了纵向采样水平。通过分析16 S rRNA基因的V1-V3区域的序列来确定它们的阴道群落的组成，并根据物种丰度的模式对它们进行分组。雌二醇，糖原，社会心理压力，和这些社区的组成之间的关系进行了assessed. Results阴道社区可以区分和分为三组，不同的丰度ofLactobacillus。81%的研究参与者的群落以乳酸菌为主。糖原水平较高的社区占主导地位的一个或多个物种的乳杆菌相比，那些有低比例的乳杆菌。三组之间的雌二醇和社会心理压力测量没有差异，而雌二醇和糖原表现出弱的正相关关系，这是不具有统计学意义的conclusionsThe研究结果表明，糖原水平与阴道社区组成的年轻黑人妇女，然而，雌二醇和社会心理压力没有。此外，研究结果表明，雌二醇水平和阴道糖原的产生之间没有简单的关系。
PurposeThe purpose of this study was to characterize the composition of vaginal bacterial communities in a cohort of black adolescent women and to determine how the species composition of these communities correlates with levels of estradiol, glycogen, and stress.MethodsTwenty-one black adolescent women were sampled longitudinally. The composition of their vaginal communities was determined by analyzing the sequences of the V1–V3 regions of 16S rRNA genes, and they were grouped based on patterns in species abundances. The relationships between estradiol, glycogen, psychosocial stress, and the composition of these communities were assessed.ResultsVaginal communities could be distinguished and classified into three groups that differed in the abundances ofLactobacillus. Eighty-one percent of study participants had communities dominated by species ofLactobacillus. Glycogen levels were higher in communities dominated by one or multiple species ofLactobacilluscompared with those having low proportions ofLactobacillus. Estradiol and psychosocial stress measurements did not differ among the three groups, whereas estradiol and glycogen exhibited a weak positive relationship that was not statistically significant.ConclusionsThe findings of this pilot study suggest that glycogen levels are associated with vaginal community composition in young black women; however, estradiol and psychosocial stress are not. In addition, the results suggest there is no simple relationship between levels of estradiol and the production of vaginal glycogen.