STEROIDS AND GROWTH-PROMOTING FACTORS IN THE REGULATION OF EXPRESSION OF GENES AND GENE NETWORKS
STEROIDS AND GROWTH-PROMOTING FACTORS IN THE REGULATION OF EXPRESSION OF GENES AND GENE NETWORKS
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DOI：
10.1016/0960-0760(92)90188-o
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发表时间：
1992-09-01
影响因子：
4.1
通讯作者：
HERRLICH, P
中科院分区：
文献类型：
--
作者：
CATO, ACB;KONIG, H;HERRLICH, P
类固醇激素和促生长因子调节一些与细胞生长和分化有关的基因的表达。在许多情况下，细胞增殖和分化的特定途径是相互排斥的。作为相互排斥机制的一个例子，负责特定途径基因表达的转录因子相互作用。类固醇激素受体抑制转录因子AP-1(Fos/Jun)的作用，反之亦然。这种抑制相互作用主要发生在蛋白质-蛋白质接触的水平上，而不需要干扰转录因子与DNA结合。在某些情况下，这两个途径的功能是相加的，甚至是协同作用的，导致转录因子在基因表达调控中的合作。本文中要讨论的例子说明了信号转导通路之间的串扰是多么复杂和重要。这些过程的微调和可逆性尤其证明了这一点。
Steroid hormones and growth promoting factors regulate the expression of a number of genes involved in cellular growth and differentiation. In many cases, cellular proliferation and differentiation-specific pathways are mutually exclusive. As an example for the mechanism of mutual exclusion, transcription factors responsible for pathway-specific gene expression interact with each other. Steroid hormone receptors inhibit the action of the transcription factor AP-1 (Fos/Jun) and vice versa. This inhibitory interaction is predominantly effected at the level of protein-protein contact without the need for the interfering transcription factor to bind to DNA. In some cases the two pathways function additively or even synergistically resulting in cooperation of the transcription factors in regulation of gene expression. The examples to be discussed in this text document how elaborate and important cross-talks between signal transduction pathways are. This is particularly demonstrated by the fine tuning and reversibility of these processes.