Neonatal androgenization in ground squirrels: influence on sex differences in body mass and luteinizing hormone levels.
Neonatal androgenization in ground squirrels: influence on sex differences in body mass and luteinizing hormone levels.
复制标题
地松鼠的新生儿雄激素化：对体重和黄体生成激素水平性别差异的影响。
DOI：
10.1095/biolreprod34.3.507
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发表时间：
1986
影响因子：
3.6
通讯作者：
Light,P
中科院分区：
文献类型：
--
作者：
Smale,L;Pelz,K;Zucker,I;Light,P
雌性松鼠出生时注射50或1000 μg丙酸睾酮（TP）；对照雄性和雌性均用油剂处理。松鼠在47日龄时进行性腺切除术。在接下来的一年中，每周记录体重，每月检测一次血浆黄体生成素（LH）。31只松鼠中有30只表现出明显的体重年周期变化。对照雄鼠和tp -雌鼠的峰体重和峰谷差异大于对照雌鼠。各组间槽体重无差异。在性腺切除后的头4个月，所有雄性和大多数雄激素化的雌性松鼠都检测到黄体生成素，但在任何对照雌性松鼠中都没有检测到。雄性松鼠的LH值峰值显著高于雌性松鼠，雌性松鼠不受新生儿雄激素化的影响。丙酸睾酮治疗也没有影响LH峰值时间的性别差异或LH可检测的总月数。我们得出结论，产后早期分泌的睾丸激素在体重变化的周期模式和黄体生成素分泌的某些方面引起性别差异。然而，完全的男性化要么需要更广泛的性腺激素的作用，可能在产前和产后都有，要么通过一些雄激素独立的机制发生。
Female squirrels were injected at birth with 50 or 1000 μg testosterone propionate (TP); control males and females were treated with oil vehicle. Squirrels were gonadectomized at 47 days of age. Body mass was recorded weekly and plasma luteinizing hormone (LH) was determined once monthly over the next year. Marked annual cycles in body mass were manifested by 30 out of 31 squirrels. Peak body mass and peak-to-trough differences were greater for control male and TP-female squirrels than for control female squirrels. Trough body weights did not differ among the groups. Luteinizing hormone was detectable in all male and most androgenized females but not in any control female squirrels during the first 4 mo after gonadectomy. Peak LH values were significantly greater for control male than for control female squirrels and were not influenced by neonatal androgenization in females. Testosterone propionate treatment also did not affect sex differences in timing of LH peaks or the total number of months in which LH was detectable. We conclude that testicular hormones secreted during the early postnatal period induce sex differences in the circannual pattern of weight change and some aspects of LH secretion. Complete masculinization, however, either requires more extensive action of gonadal hormones, perhaps both pre- and postnatally, or occurs through some androgen-independent mechanism.