Transforming growth factor β: a master regulator of the gut microbiota and immune cell interactions.
Transforming growth factor β: a master regulator of the gut microbiota and immune cell interactions.
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转化生长因子β：肠道微生物群与免疫细胞相互作用的主要调节因子。
DOI：
10.1038/cti.2017.9
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发表时间：
2017-04
影响因子：
5.8
通讯作者：
Marie JC
中科院分区：
文献类型：
--
作者：
Bauché D;Marie JC
宿主生物与其微生物群之间的关系共同演化为相互依存的互利相互作用网络。这种相互作用在胃肠道中得到了特别深入的研究，其中微生物群和宿主免疫细胞可以通过化学分子和信号的产生和释放直接或间接地相互调节。在这篇综述中，我们定义了转化生长因子-β (TGF-β) 对这种复杂相互作用的功能影响，特别是通过其调节局部调节 T 细胞 (Treg)、17 型辅助细胞 (Th17)、先天淋巴细胞 (ILC) 和 B 细胞的活性。
The relationship between host organisms and their microbiota has co-evolved towards an inter-dependent network of mutualistic interactions. This interplay is particularly well studied in the gastrointestinal tract, where microbiota and host immune cells can modulate each other directly, as well as indirectly, through the production and release of chemical molecules and signals. In this review, we define the functional impact of transforming growth factor-beta (TGF-β) on this complex interplay, especially through its modulation of the activity of local regulatory T cells (Tregs), type 17 helper (Th17) cells, innate lymphoid cells (ILCs) and B cells.