Ultrashort-Echo Time MR Imaging of the Patella with Bicomponent Analysis: Correlation with Histopathologic and Polarized Light Microscopic Findings
Ultrashort-Echo Time MR Imaging of the Patella with Bicomponent Analysis: Correlation with Histopathologic and Polarized Light Microscopic Findings
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DOI：
10.1148/radiol.12111883
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发表时间：
2012-08-01
期刊：
影响因子：
19.7
通讯作者：
Du, Jiang
中科院分区：
文献类型：
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作者：
Pauli, Chantal;Bae, Won C.;Du, Jiang
目的：将超短回波时间（TE）磁共振（MR）成像获得的短和长T2*水组分与人尸体髌骨软骨的半定量组织病理学和偏光显微镜（PLM）评估相关联。材料和方法：经机构审查委员会批准，采用超短te成像、自旋回波成像、组织病理学分析和PLM对20具人尸体髌骨进行评估。采用超短te信号衰减双分量拟合评估各髌骨的短、长T2*水分量。每个髌骨内选择4至6个感兴趣区域（roi），用于超短te双组分分析、组织病理学分级（Mankin评分）和PLM分级（Vaudey评分）之间的相关性。结果：超短te成像双组分分析显示两种不同的水组分，所有髌骨T2*短，T2*长。ROI分析显示，T2*短分数与Mankin评分（rho = 0.66, P < 0.001）和Vaudey评分（rho = 0.68, P < 0.001）显著相关。Mankin评分与T2 （rho = 0.28, P = 0.13）、T2*短（rho = 0.24, P = 0.14）呈弱正相关，与T2*长（rho = -0.55, P < 0.01）呈负相关。Vaudey评分与T2 （rho = 0.18, P = 0.16）、T2*短（rho = 0.22, P = 0.14）呈弱正相关，与T2*长呈负相关（rho = -0.55, P < 0.01）。结论：采用双组分分析的超短te成像获得的短T2*水分数与Mankin和Vaudey评分均有显著相关性，可能作为软骨退变的生物标志物。(c) RSNA， 2012年
Purpose: To correlate short and long T2* water fractions, derived from ultrashort-echo time (TE) magnetic resonance (MR) imaging, with semiquantitative histopathologic and polarized light microscopic (PLM) assessment of human cadaveric patellae cartilage.Materials and Methods: Twenty human cadaveric patellae were evaluated by using ultrashort-TE imaging, spin-echo imaging, histopathologic analysis, and PLM, with institutional review board approval. Short and long T2* water components were evaluated for each patella by using bicomponent fitting of ultrashort-TE signal decay. Four to six regions of interest (ROIs) within each patella were chosen for correlation between ultrashort-TE bicomponent analysis, histopathologic grading (Mankin score), and PLM grading (Vaudey score).Results: Ultrashort-TE imaging with bicomponent analysis showed two distinct water components with a short T2* and a longer T2* in all patellae. ROI analysis showed that the short T2* fraction was correlated significantly with the Mankin (rho = 0.66, P < .001) and Vaudey (rho = 0.68, P < .001) scores. The Mankin scores were weakly positively correlated with T2 (rho = 0.28, P = .13) and short T2* (rho = 0.24, P = .14) but were negatively correlated with long T2* (rho = -0.55, P < .01). The Vaudey scores were weakly positively correlated with T2 (rho = 0.18, P = .16) and short T2* (rho = 0.22, P = .14) but were negatively correlated with long T2* (rho = -0.55, P < .01).Conclusion: Short T2* water fraction derived from ultrashort-TE imaging with bicomponent analysis correlates significantly with both the Mankin and Vaudey scores and may serve as a biomarker of cartilage degeneration. (c) RSNA, 2012