The Structure of the Genetic and Environmental Influences on Mental Well-Being
The Structure of the Genetic and Environmental Influences on Mental Well-Being
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DOI：
10.2105/ajph.2010.193615
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发表时间：
2010-12-01
影响因子：
12.7
通讯作者：
Kendler, Kenneth S.
中科院分区：
文献类型：
--
作者：
Keyes, Corey L. M.;Myers, John M.;Kendler, Kenneth S.
目的探讨遗传和环境因素对心理健康3个维度的影响结构。方法选取349对同卵双生子和321对异卵双生子为研究对象，分别完成情绪、心理和社会健康3个维度的自我报告。结果最佳拟合模型包含3个维度的共同路径没有共同的环境影响，男性和女性有一组参数，潜在心理健康因素的遗传力很高（72%）心理幸福感是最好的指标，情绪和社会幸福感有中等的特质特异性遗传效应，所有指标的非共享环境效应大多是特质特异性的。结论心理幸福感的遗传影响反映了一个高度遗传的单一因素。遗传因素，虽然一些性状特异性遗传影响被视为情绪和社会福祉中等比例或环境影响也共享，但大多数独特的环境是性状特异性的（美国公共卫生杂志2010 100 2379-2384 doi 10 2105/AJPH 2010 193615）
Objectives We sought to investigate the structure of the genetic and environmental influences on 3 measures of mental well beingMethods Analyses focused on the subsample of 349 monozygotic and 321 dizygotic same sex twin pairs from a nationally representative sample of twins who completed self report measures of emotional psychological and social well beingResults The best fit model contained a common pathway to all 3 measures of well being no shared environmental effects and 1 set of parameters for men and women Heritability for the latent mental well being factor was high (72%) and best indexed by psychological well being Moderate trait specific genetic effects were seen for emotional and social well being Nonshared environmental effects for all measures were mostly trait specificConclusions Genetic influences on the measures of mental well being reflect a single highly heritable genetic factor although some trait specific genetic influences were seen for emotional and social well being Moderate proportions or environmental influences were also shared but the majority of unique environment was trait specific (Am J Public Health 2010 100 2379-2384 doi 10 2105/AJPH 2010 193615)