Iodine-131-labeled MAb F(ab')2 fragments are more efficient and less toxic than intact anti-CEA antibodies in radioimmunotherapy of large human colon carcinoma grafted in nude mice.
Iodine-131-labeled MAb F(ab')2 fragments are more efficient and less toxic than intact anti-CEA antibodies in radioimmunotherapy of large human colon carcinoma grafted in nude mice.
复制标题
在裸鼠移植的大结肠癌的放射免疫治疗中，碘 131 标记的 MAb F(ab)2 片段比完整的抗 CEA 抗体更有效且毒性更小。
作者：
F. Buchegger;A. Pèlegrin;B. Delaloye;A. Bischof;J. Mach
During one week, beginning 18 days after transplantation, nude mice bearing human colon carcinoma ranging from 115 to 943 mm3 (mean 335 mm3) were treated by repeated intravenous injections of either iodine-131-(131I) labeled intact antibodies or 131I-labeled corresponding F(ab')2 fragments of a pool of four monoclonal antibodies (MAbs) directed against distinct epitopes of carcinoembryonic antigen (CEA). Complete tumor remission was observed in 8 of 10 mice after therapy with F(ab')2 and 6 of the animals survived 10 mo in good health. In contrast, after treatment with intact MAbs, tumors relapsed in 7 of 8 mice after remission periods of 1 to 3.5 mo despite the fact that body weight loss and depression of peripheral white blood cells, symptoms of radiation toxicity, and the calculated radiation doses for liver, spleen, bone, and blood were increased or equal in these animals as compared to mice treated with F(ab')2.
使用针对人乳脂肪球制备的 131I 标记单克隆抗体对人乳腺肿瘤进行实验性治疗。
影响因子：
11.2
作者：
Ceriani,RL;Blank,EW
通讯作者：
Blank,EW
通过单克隆抗体对人类肿瘤异种移植物进行放射免疫检测。
影响因子：
11.2
作者：
Herlyn,D;Powe,J;Alavi,A;Mattis,JA;Herlyn,M;Ernst,C;Vaum,R;Koprowski,H
通讯作者：
Koprowski,H