Evaluating Glyphosate Exposure Routes and Their Contribution to Total Body Burden: A Study Among Amenity Horticulturalists
Evaluating Glyphosate Exposure Routes and Their Contribution to Total Body Burden: A Study Among Amenity Horticulturalists
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DOI：
10.1093/annweh/wxy104
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发表时间：
2019-03-01
影响因子：
2.6
通讯作者：
Basinas, Ioannis
中科院分区：
文献类型：
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作者：
Connolly, Alison;Coggins, Marie A.;Basinas, Ioannis
目的：评估皮肤和无意摄入暴露的决定因素，并评估其对使用草甘膦农药产品的休闲园艺使用者总体负担的影响。方法：在休闲园艺工作者中完成了皮肤和无意摄入暴露评估，同时进行了生物监测研究。精心设计了线性混合效应回归模型，以评估暴露的决定因素及其对总体身体负担的影响。结果：从 20 名工作人员的 29 项工作任务中收集了总共 343 个擦拭巾和手套样本。在工人口周区域和左右手的擦拭巾上测得的几何平均（GM）草甘膦浓度分别为0.01、0.04和0.05μg·cm(-2)。对于一次性和可重复使用的手套，检测到的GM草甘膦浓度分别为0.43和7.99μg cm(-2)。手部和口周区域的合并草甘膦浓度解释了尿液 (μ g l(-1)) 生物监测数据中 40% 的差异。 结论：据作者所知，这是第一项调查皮肤和无意接触草甘膦及其对总体身体负担的影响的研究。数据显示，与无意摄入相比，皮肤暴露是主要的暴露途径，但无意摄入可能会增加整体身体负担。该研究还确定了工作场所中非农药使用者的潜在接触和准职业接触。
Objective: To evaluate determinants of dermal and inadvertent ingestion exposure and assess their contribution to total body burden among amenity horticultural users using glyphosate-based pesticide products.Methods: A dermal and inadvertent ingestion exposure assessment was completed alongside a biomonitoring study among amenity horticultural workers. Linear mixed effect regression models were elaborated to evaluate determinants of exposure and their contribution to total body burden.Results: A total of 343 wipe and glove samples were collected from 20 workers across 29 work tasks. Geometric mean (GM) glyphosate concentrations of 0.01, 0.04 and 0.05 mu g cm(-2) were obtained on wipes from the workers perioral region and left and right hands, respectively. For disposable and reusable gloves, respectively, GM glyphosate concentrations of 0.43 and 7.99 mu g cm(-2) were detected. The combined hand and perioral region glyphosate concentrations explained 40% of the variance in the urinary (mu g l(-1)) biomonitoring data.Conclusion: To the authors knowledge, this is the first study to have investigated both dermal and inadvertent exposure to glyphosate and their contribution to total body burden. Data show the dermal exposure is the prominent route of exposure in comparison to inadvertent ingestion but inadvertent ingestion may contribute to overall body burden. The study also identified potential exposure to non-pesticide users in the workplace and para-occupational exposures.