Tissue factor expression and tumor-infiltrating T lymphocytes in ovarian carcinomas and their association with venous thromboembolism
Tissue factor expression and tumor-infiltrating T lymphocytes in ovarian carcinomas and their association with venous thromboembolism
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卵巢癌组织因子表达和肿瘤浸润T淋巴细胞及其与静脉血栓栓塞的关系
DOI：
10.1111/pin.13074
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发表时间：
2020
影响因子：
2.2
通讯作者：
Sato Y.
中科院分区：
文献类型：
--
作者：
Gi T;Yamashita A;Aman M;Kuwahara A;Asada Y;Kawagoe Y;Onishi J;Sameshima H;Sato Y.
卵巢癌是静脉血栓栓塞 (VTE) 的已知危险因素。子宫内膜异位症和卵巢癌中已有血栓形成因子表达和淋巴细胞浸润的报道。我们回顾了 30 例卵巢癌（高级别浆液性癌，10 例；子宫内膜样癌，10 例；透明细胞癌 (CCC)，10 例）和 16 例子宫内膜异位病变。我们通过免疫组织化学方法研究了癌组织和子宫内膜异位病灶中组织因子（TF）、足足蛋白、P-选择素的表达以及CD4和CD8阳性淋巴细胞的数量，及其与VTE的关系。 CCC中TF表达较高。发生VTE的癌组织中TF表达量和CD8阳性细胞数均高于未发生VTE的癌组织。平足蛋白或 P-选择素的表达在组织学类型之间或有无 VTE 的病例之间没有差异。我们的结果表明 CCC 中存在高 TF 表达和上皮内 CD8 细胞，这与 VTE 相关。结果表明，浸润淋巴细胞可能影响 TF 表达，进而影响 VTE。
Ovarian cancer is a known risk factor of venous thromboembolism (VTE). Thrombogenic factor expression and lymphocytic infiltrate have been reported in endometriosis and ovarian cancers. We reviewed 30 cases of ovarian carcinomas (high grade serous carcinoma, 10; endometrioid carcinoma, 10; clear cell carcinoma (CCC), 10) and 16 endometriotic lesions. We immunohistochemically investigated the expressions of tissue factor (TF), podoplanin, P‐selectin, and number of CD4 and CD8 positive lymphocytes in cancer tissue and endometriotic lesions, along with their relationship with VTE. The expression of TF was higher in CCC. The TF expression and the number of CD8 positive cells were higher in cancer tissues with VTE than in those without VTE. The podoplanin or P‐selectin expression did not differ among histological types or between cases with and without VTE. Our results demonstrated a high TF expression and intraepithelial CD8 cells in CCC, which were associated with VTE. The results suggest that infiltrating lymphocytes may affect TF expression that, in turn, influences VTE.