Magnetic resonance spectroscopy: A promising tool for the diagnostics of human prostate cancer?
Magnetic resonance spectroscopy: A promising tool for the diagnostics of human prostate cancer?
复制标题
DOI：
10.1016/j.urolonc.2011.05.016
复制
发表时间：
2011-09-01
影响因子：
2.7
通讯作者：
Cheng, Leo L.
中科院分区：
文献类型：
--
作者：
Kurth, Johannes;DeFeo, Elita;Cheng, Leo L.
背景：前列腺癌（Prostate Cancer，CaP）是世界范围内最常见的恶性肿瘤之一。在发达国家，早期癌症检测方法在过去几十年中导致发病率增加;然而，预后差异很大。有没有诊断工具的准确预测肿瘤的侵袭性，因此缺乏足够的和最佳的治疗planning.Methods：电子数据库（Medline，PubMed）进行扫描的科学文献。本文对磁共振波谱（MRS）的基本概念、重要研究成果及其临床应用进行了综述。结论：MRS可提供有关前列腺组织代谢状态的重要信息，同时可保存标本以供进一步研究。可以量化单个代谢物和代谢组学谱，以区分良性组织和恶性组织，并预测侵袭性，例如CaP的复发率。研究还预计，MRS可能是有益的，适用于在体内研究的未来。(C)2011 Elsevier Inc. All rights reserved.
Background: Prostate Cancer (CaP) is one of the topmost diagnosed malignant diseases worldwide. In developed countries, early cancer detection methods have led to an increase of incidence rates over the last decades; however, with great variance of the prognosis. There is no diagnostic tool for an exact prediction of tumor aggressiveness, thus there is a lack of adequate and optimal treatment planning.Methods: Electronic databases (Medline, PubMed) were scanned for scientific literature. Basic concepts of magnetic resonance spectroscopy (MRS), important results and its clinical applications were extracted and reviewed in this article.Conclusions: MRS provides crucial information about the metabolic status of human prostate samples while preserving the specimens for further investigations. Single metabolites and metabolomic profiles can be quantified to distinguish benign from malignant tissue and to predict aggressiveness, such as the recurrence rates of CaP. Studies are also anticipating that MRS might be beneficially applicable for in vivo investigations in the future. (C) 2011 Elsevier Inc. All rights reserved.