Blood and dietary magnesium levels are not linked with lower prostate cancer risk in black or white men
Blood and dietary magnesium levels are not linked with lower prostate cancer risk in black or white men
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DOI：
10.1016/j.canlet.2019.02.023
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发表时间：
2019-01-01
期刊：
影响因子：
9.7
通讯作者：
Freedland, Stephen J.
中科院分区：
文献类型：
--
作者：
Fowke, Jay H.;Koyama, Tatsuki;Freedland, Stephen J.
最近的研究表明，膳食镁摄入量低或血镁水平较低的饮食与前列腺癌风险增加有关。这项研究调查了血液镁和钙水平，或膳食镁摄入量与低级别和高级别前列腺癌诊断之间的种族特异性联系。该研究包括从田纳西州纳什维尔或北卡罗来纳州达勒姆招募的637例前列腺癌病例和715例活检阴性对照（50%黑人）。在招募时采集血液，通过食物频率问卷评估饮食摄入。百分之遗传非洲血统被确定为自我报告的种族的恭维。与白色男性相比，黑人的血镁水平和膳食镁摄入量明显较低。然而，镁水平或摄入量与总前列腺癌或侵袭性前列腺癌的风险无关。事实上，较高的钙镁饮食摄入量对黑人（OR = 0.66（0.45，0.96），p = 0.03）而不是白色男性（OR = 1.00（0.79，1.26），p = 0.99）的高级前列腺癌具有显著的保护作用。总之，黑人和白色男性之间镁摄入量存在统计学显著差异，但生物学影响尚不清楚，我们没有证实镁水平与前列腺癌风险降低有关。
Recent studies suggest a diet low in dietary magnesium intake or lower blood magnesium levels is linked with increased prostate cancer risk. This study investigates the race-specific link between blood magnesium and calcium levels, or dietary magnesium intake, and the diagnosis of low-grade and high-grade prostate cancer. The study included 637 prostate cancer cases and 715 biopsy-negative controls (50% black) recruited from Nashville, TN or Durham, NC. Blood was collected at the time of recruitment, and dietary intake was assessed by food frequency questionnaire. Percent genetic African ancestry was determined as a compliment to self-reported race. Blood magnesium levels and dietary magnesium intake were significantly lower in black compared to white men. However, magnesium levels or intake were not associated with risk of total prostate cancer or aggressive prostate cancer. Indeed, a higher calcium-to-magnesium diet intake was significantly protective for high-grade prostate cancer in black (OR = 0.66 (0.45, 0.96), p = 0.03) but not white (OR = 1.00 (0.79, 1.26), p = 0.99) men. In summary, there was a statistically significant difference in magnesium intake between black and white men, but the biological impact was unclear, and we did not confirm a lower prostate cancer risk associated with magnesium levels.