Amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis
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DOI：
10.53347/rid-70821
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发表时间：
2019-09
期刊：
影响因子：
--
通讯作者：
Rohit Sharma;Y. Voss
中科院分区：
文献类型：
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作者：
Rohit Sharma;Y. Voss
运动神经元病是指几种影响运动神经元的疾病，有时可互换使用，指肌萎缩侧索硬化症(ALS)，这是最常见的运动神经元病。本章重点介绍肌萎缩侧索硬化症。ALS是分子途径和细胞相互作用的复杂组合。大约10%的ALS病例是遗传的，尽管有假设说，随着更多的基因被发现与疾病有关，更大比例的病例将被引用。本章详细讨论了肌萎缩侧索硬化症最常见的遗传形式以及目前靶向治疗的研究。
The term motor neuron disease refers to several diseases affecting the motor neurons and is sometimes used interchangeably to refer to amyotrophic lateral sclerosis (ALS), which is the most common motor neuron disease. This chapter will focus on ALS. A complex combination of molecular pathways and cell interactions cause ALS. About 10% of ALS cases are genetic, although it has been hypothesized that as more genes are discovered to contribute to the disease, a larger percentage of cases will be quoted. This chapter discusses in detail the most common genetic forms of ALS and current research on targeted treatments.