The effects of interaction between familial and reproductive factors on breast cancer risk:: a combined analysis of seven case-control studies
The effects of interaction between familial and reproductive factors on breast cancer risk:: a combined analysis of seven case-control studies
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DOI：
10.1038/bjc.1998.251
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发表时间：
1998-05-01
影响因子：
8.8
通讯作者：
Day, NE
中科院分区：
文献类型：
--
作者：
Andrieu, N;Smith, T;Day, NE
本文采用综合分析的方法研究了家庭危险因素与生育寿命因素之间的交互作用。特别是，家族性风险和乳腺细胞有丝分裂活性（BCMA）之间的相互作用，卵巢活动的持续时间进行了评估，因为有丝分裂活性对遗传易感细胞的潜在重要性进行了研究。本分析包括来自4个国家的7项病例对照研究中的3152例病例和4404例对照。在每项研究中分别估计相互作用效应，然后使用两种不同的方法合并：多变量加权平均和贝叶斯随机效应模型。生殖生活因素对乳腺癌发病风险的主要影响与以往的研究结果一致。特别是，在第一次分娩前和一生中BCMA的持续时间增加会增加乳腺癌的风险（P < 0.001）。随着孩子数量的增加（P = 0.17），首次分娩年龄的增加（P > 0.2）和BCMA持续时间的增加（P > 0.2），观察到轻微增加但不显著的常见风险。家族性风险没有随初潮年龄的变化而改变，也没有明确的绝经特征模式。本研究显示，生殖和月经因素对家族性风险的影响较弱。
In this paper, a combined analysis was performed to study the interaction between familial risk and reproductive life factors. In particular, the interaction between familial risk and breast cell mitotic activity (BCMA), as assessed by duration of ovarian activity, was investigated because of the potential importance of mitotic activity on genetically susceptible cells. The present analysis included 3152 cases and 4404 controls in seven case-control studies from four countries. The interaction effect was estimated in each study separately, then combined using two different methods: a multivariate weighted average and a Bayesian random-effects model. The main effects of reproductive life factors on the risk of breast cancer were in agreement with the previous findings. In particular, an increased duration of BCMA before the first childbirth and over life was found to increase the risk of breast cancer (P < 0.001). Slightly increasing but non-significant, familiar risks were observed with increasing number of children (P = 0.17), increasing age at first childbirth (P > 0.2) and increasing duration of BCMA (P > 0.2). There was no modification in familial risk with age at menarche and no clear pattern with menopause characteristics. A weak influence of reproductive and menstrual factors on the familial risk emerged from the present study.