Immunoglobulin E levels in relationship to HIV-1 disease, route of infection, and vitamin E status.
Immunoglobulin E levels in relationship to HIV-1 disease, route of infection, and vitamin E status.
复制标题
免疫球蛋白 E 水平与 HIV-1 疾病、感染途径和维生素 E 状态的关系。
DOI：
10.1111/j.1398-9995.1995.tb05073.x
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发表时间：
1995
期刊：
影响因子：
12.4
通讯作者：
Baum,MK
中科院分区：
文献类型：
--
作者：
Miguez-Burbano,MJ;Shor-Posner,G;Fletcher,MA;Lu,Y;Moreno,JN;Carcamo,C;Page,B;Quesada,J;Sauberlich,H;Baum,MK
Our recent studies have demonstrated that in early HIV‐1 infection, elevation of plasma immunoglobulin E (IgE) levels precedes the decline of CD4 cell count and is influenced by vitamin E status. In order to further investigate the role of IgE elevation in HIV‐1 infection, we determined IgE levels in HIV‐1‐seropositive and ‐seronegative intravenous drug users (IDUs) (n= 38), in relationship to cellular and humoral immune function, liver enzymes, and vitamin E status. To examine the possible impact of the route of HIV‐1 infection on IgE levels, comparisons between the cohorts of the HIV‐1‐seropositive and ‐seronegative IDUs and homosexual men (n= 45) were also conducted. All HIV‐1‐seropositive participants had significantly higher (P= 0.003) IgE levels than the HIV‐1‐seronegative subjects. The HIV‐1‐seropositive IDUs, moreover, demonstrated significantly higher (P= 0.01) IgE levels than HIV‐1‐seropositive homosexual men, despite similar CD4 cell counts. Stepwise regression analysis was used to evaluate the possible variables contributing to the IgE variation. HIV‐1 status (P= 0.0009), intravenous drug use (P= 0.014), CD8 cell counts (P= 0.0001), plasma level of vitamin E (P= 0.006), and alcohol intake (P= 0.047) were significant, accounting for 71% of the IgE elevation. These findings suggest that IgE may serve as a sensitive marker to reflect the evolution of HIV‐1 disease in individuals from different risk groups.
