The role of HIV infection in the etiology and epidemiology of diarrheal disease among children aged 0-59 months in Manhica District, Rural Mozambique
The role of HIV infection in the etiology and epidemiology of diarrheal disease among children aged 0-59 months in Manhica District, Rural Mozambique
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DOI：
10.1016/j.ijid.2018.05.012
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发表时间：
2018-08-01
影响因子：
8.4
通讯作者：
Bassat, Quique
中科院分区：
文献类型：
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作者：
Acacio, Sozinho;Nhampossa, Tacilta;Bassat, Quique
背景：腹泻是 HIV 感染者的一个重要健康问题。本研究评估了 HIV 在儿童腹泻病的流行病学、病因学和严重程度中的作用。 方法：全球肠道多中心研究招募了 2007 年 12 月至 2012 年 11 月期间患有中重度腹泻 (MSD) 和轻度腹泻 (LSD) 的儿童。招募了 1 至 3 名 MSD 病例对照者，每例 LSD 病例 1 名，并按年龄、性别和社区进行匹配。所有儿童都接受了艾滋病毒检测。收集临床数据、人体测量数据和粪便样本。 60 天后进行随访。结果：测试了 214 名 MSD 病例和 418 名对照者，以及 349 名 LSD 病例和 214 名对照者。 MSD 病例中的 HIV 患病率为 25%（匹配对照者为 4%），LSD 病例中 HIV 患病率为 6%（匹配对照者为 6%）。 HIV 感染儿童更有可能患有 MSD（比值比 5.6，p
Background: Diarrhea is an important health problem among HIV-infected patients. This study evaluated the role of HIV in the epidemiology, etiology, and severity of diarrheal disease among children.Methods: The Global Enteric Multicenter Study enrolled children with moderate-to-severe diarrhea (MSD) and less-severe diarrhea (LSD) between December 2007 and November 2012. One to three controls for MSD cases and one per LSD case were enrolled and matched by age, sex, and neighborhood. All children were tested for HIV. Clinical data, anthropometric data, and stool samples were collected. Follow-up was performed at 60 days.Results: Two hundred and fourteen MSD cases and 418 controls, together with 349 LSD cases and 214 controls were tested. HIV prevalence was 25% among MSD cases (4% for matched controls) and 6% among LSD cases (6% among matched controls). HIV-infected children were more likely to have MSD (odds ratio 5.6, p