Enantioselective nickel-catalyzed Mizoroki-Heck cyclizations of amide electrophiles.
Enantioselective nickel-catalyzed Mizoroki-Heck cyclizations of amide electrophiles.
复制标题
酰胺亲电子试剂的对映选择性镍催化 Mizoroki-Heck 环化。
DOI：
10.1039/d3sc05797f
复制
发表时间：
2024
期刊：
影响因子：
8.4
通讯作者：
Garg,NeilK
中科院分区：
文献类型：
--
作者：
Bulger,AnaS;Nasrallah,DanielJ;TenaMeza,Arismel;Garg,NeilK
Amide cross-couplings that rely on C–N bond activation by transition metal catalysts have emerged as valuable synthetic tools. Despite numerous discoveries in this field, no catalytic asymmetric variants have been disclosed to date. Herein, we demonstrate the first such transformation, which is the Mizoroki–Heck cyclization of amide substrates using asymmetric nickel catalysis. This proof-of-concept study provides an entryway to complex enantioenriched polycyclic scaffolds and advances the field of amide C–N bond activation chemistry.
