Irritable bowel syndrome and migraine: evidence from Mendelian randomization analysis in the UK Biobank
Irritable bowel syndrome and migraine: evidence from Mendelian randomization analysis in the UK Biobank
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DOI：
10.1080/17474124.2021.1949290
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发表时间：
2021-07-21
影响因子：
3.9
通讯作者：
Hesketh, Therese
中科院分区：
文献类型：
--
作者：
Chen, Jie;Chen, Xuejie;Hesketh, Therese
背景肠易激综合征（IBS）和偏头痛是两种高发疾病。先前的研究表明肠易激综合征和偏头痛之间存在关系，尽管因果关系尚不清楚。作者试图探索肠易激综合征和偏头痛之间的因果关系，并表明预防偏头痛对肠易激综合征患者的重要性。方法采用孟德尔随机分析方法，探讨肠易激综合征与偏头痛的关系。从英国生物银行（UKB）遗传数据库中获得与偏头痛的遗传关联（病例：1,072例；对照组：360,122例）。作者使用逆方差加权（IVW）进行估计，同时使用最大似然、MR-RAPS、MR-Egger和加权中位数进行敏感性分析。考虑到可能存在的偏倚，他们还进行了多态性、异质性和方向性分析。结果IVW估计遗传预测IBS和偏头痛之间的因果关系（OR = 1.09, 95% CI 1.01 ~ 1.17, p = 0.03）。未发现统计学水平多效性（MR Egger p = 0.42; MR- presso p = 0.78）和异质性（IVW Q = 26.15, p = 0.80）。反向因果关系也未发现（p steiger）
Background Irritable Bowel Syndrome (IBS) and Migraine are two diseases featuring high prevalence. Previous studies have suggested a relationship between IBS and migraine, although the causal association remains unclear. The authors sought to explore the causal association between IBS and migraine, and to show the importance of migraine prevention in IBS patients. Methods This study conducted a Mendelian randomization analysis to explore the association of IBS with migraine. Genetic association with migraine was acquired from the UK Biobank (UKB) genetic databases (cases: 1,072; controls: 360,122). The authors performed estimation using Inverse Variance Weighting (IVW), along with Maximum Likelihood, MR-RAPS, MR-Egger, and Weighted Median for sensitivity analysis. Considering possible bias, they also conducted polymorphism, heterogeneity, and directional analysis. Results The IVW estimation genetically predicted the causal association between IBS and migraine (OR = 1.09, 95% CI 1.01 to 1.17, p = 0.03). Neither statistical horizontal pleiotropy (MR Egger p = 0.42; MR-PRESSO p = 0.78) nor possible heterogeneity (IVW Q = 26.15, p = 0.80) was found. Reverse causation was also not detected (p steiger