Lesions of Ventrolateral Prefrontal or Anterior Orbitofrontal Cortex in Primates Heighten Negative Emotion
Lesions of Ventrolateral Prefrontal or Anterior Orbitofrontal Cortex in Primates Heighten Negative Emotion
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DOI：
10.1016/j.biopsych.2012.03.007
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发表时间：
2012-08-15
影响因子：
10.6
通讯作者：
Roberts, Angela C.
中科院分区：
文献类型：
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作者：
Agustin-Pavon, Carmen;Braesicke, Katrin;Roberts, Angela C.
背景：高度恐惧和焦虑是各种神经精神障碍的核心症状。它们与整个神经回路的结构和活动变化有关，包括腹侧和内侧前额叶皮质(PFC)、杏仁核和海马体。虽然内侧前额叶、杏仁核和海马体在恐惧和焦虑中的作用已经在动物模型中得到了广泛的研究，但腹侧前额叶皮质(包括腹外侧前额叶皮质和眶前额叶皮质)的选择性作用尚不清楚。方法：我们研究了选择性兴奋毒性损毁VLPFC或前眶前额叶皮质对新世界灵长类动物焦虑行为和巴甫洛夫条件性自主神经和行为恐惧反应的影响。结果：VLPFC和ANTOFC损伤都导致了更强的、适应性较差的恐惧反应。它们还增强了一只绒猴对人类入侵者的焦虑反应。相反，只有VLPFC的损伤影响了绒猴在人类入侵者面前表现出的应对方式，增加了主动移动的可能性。结论：这些结果表明，antOFC和VLPFC都可以下调恐惧和焦虑，共同为自上而下控制负面情绪提供必要但独立的贡献。
Background: Heightened fear and anxiety are core symptoms of a variety of neuropsychiatric disorders. They are associated with structural and activity changes throughout neural circuitry that includes the ventral and medial prefrontal cortices (PFC), the amygdala, and hippocampus. Although the contributions of the medial PFC, amygdala, and hippocampus to fear and anxiety have been studied extensively with animal models, the selective roles of the ventral PFC-including the ventrolateral prefrontal cortex (vlPFC) and orbitofrontal cortex-are poorly understood.Methods: We investigated the effects of selective excitotoxic lesions of either the vlPFC or anterior orbitofrontal cortex (antOFC) on anxious behavior and Pavlovian conditioned autonomic and behavioral fear responses in the New World primate, the common marmoset.Results: Both vlPFC and antOFC lesions resulted in stronger, less adaptable conditioned fear responses. They also heightened the anxiety responses of a marmoset to a human intruder. In contrast, only a lesion of the vlPFC affected the coping style that a marmoset displayed in the presence of the human intruder, increasing the likelihood of proactive mobbing.Conclusions: These results suggest that both the antOFC and vlPFC can downregulate fear and anxiety and, together, provide necessary but independent contributions to the top-down control of negative emotion.