Precision delivery of liquid therapy into the arterial wall for the treatment of peripheral arterial disease.
Precision delivery of liquid therapy into the arterial wall for the treatment of peripheral arterial disease.
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DOI：
10.1038/s41598-021-98063-z
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发表时间：
2021-09-21
影响因子：
4.6
通讯作者：
Yazdani SK
中科院分区：
文献类型：
--
作者：
Atigh MK;Goel E;Erwin M;Greer R 2nd;Ohayon J;Pettigrew RI;Yazdani SK
灌注导管最近已成为一种将液体抗增殖剂输送到血流阻塞动脉段的新方法。本研究的目的是确定管腔输送压力对液体药物渗透到血管壁中的影响。使用采集的猪颈动脉的离体模型和二维计算模型来确定液体治疗的输送压力对动脉壁的影响。猪外周损伤模型确定了腔内递送压力对药物保留的影响。离体结果表明，液体渗透深度从0 atm时的6.93 ± 1.90%变化到0.4 atm时的27.75 ± 6.61%。计算结果具有相似的结果，因为渗透率在4.4%和22.84%之间变化。体内结果表明，在1小时（23.43 ± 13.59 ng/mg vs. 2.49 ± 1.81 ng/mg，p = 0.026）和7天（0.50 ± 0.39 ng/mg vs. 0.018 ± 0.023 ng/mg，p = 0.0496）时，0.4 atm与0.1 atm下向动脉组织的药物递送显著增加。这项研究的结果提供了一种创新的战略和技术方法，使有针对性的液体治疗。
Perfusion catheters have recently emerged as a novel approach to deliver liquid anti-proliferative agents into flow obstructed arterial segments. The purpose of this study was to determine the impact of luminal delivery pressure on liquid drug penetration into the vessel wall. An ex vivo model using harvested porcine carotid arteries and a two-dimensional computational model were utilized to determine the impact of delivery pressure of liquid therapy into the arterial wall. A pig peripheral injury model determined the impact of intra-luminal delivery pressure on drug retention. Ex vivo results demonstrated that depth of fluid penetration varies from 6.93 ± 1.90% at 0 atm to 27.75 ± 6.61% penetration of the medial layer at 0.4 atm. Computational results had similar outcomes, as penetration varied between 4.4% and 22.84%. The in vivo results demonstrated significant increase in drug delivery to the arterial tissue at 0.4 atm versus 0.1 atm at 1 h (23.43 ± 13.59 ng/mg vs. 2.49 ± 1.81 ng/mg, p = 0.026) and 7 days (0.50 ± 0.39 ng/mg vs. 0.018 ± 0.023 ng/mg, p = 0.0496). The result of this study provides an innovative strategic and technical approach to enable targeted liquid therapy.
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影响因子：
4.6
作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
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影响因子：
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作者：
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DOI：
10.1152/ajpheart.00324.2009
发表时间：
2009-09-01
影响因子：
4.8
作者：
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通讯作者：
Tarbell, John M.